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首页> 外文期刊>International Journal of Infection Control >Surveillance of antibiotic use and resistance in Orthopaedic Department in an Egyptian University Hospital
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Surveillance of antibiotic use and resistance in Orthopaedic Department in an Egyptian University Hospital

机译：埃及大学医院骨科的抗生素使用和耐药性监测

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Antimicrobial use and subsequently antimicrobial resistance among bacterial pathogens is a global problem, but in Egypt data are sparse. Orthopaedic departments reflect this problem because in them surgery constitutes the main manipulation and septic diseases constitute common complications both need guided antimicrobial therapy otherwise antimicrobial resistance will emerge. In order to highlight these issues, a prospective 9-month study on antimicrobial use and the antimicrobial susceptibility patterns of the isolated organisms in Orthopaedic Department, Tanta University, Egypt was carried out. High antimicrobial prescription rates (98.1%) with low rates of appropriateness (11.3%) were detected. Eighty-one percent of prescribed antimicrobial agents belong to cephalosporins and penicillins classes. Antibiotics were given for prophylaxis continued post-operatively (77%), for infections (13.4%) as well as randomly (22%). High rates of resistance were found in most of the bacteria studied. 53.3% of Staphylococcus aureus (S. aureus) and 66.7% of coagulase-negative staphylococcus (CNS) isolates were oxacillin resistant. Multi-resistant strains represented 48.6% of the isolated gram negative strains of which 29.2% were ESBL (Klebsiella 62.5% and E. coli 33.3%) while 19.4% were MR Pseudomonas and Acinetobacter isolates. Antibiotic treatment in our Orthopaedic Department appears to be substantial. Increasing and justifying efforts are needed to improve appropriateness of antimicrobial therapy and minimize the development of antimicrobial resistance. We also call for a nationwide surveillance programme to monitor microbial trends and antimicrobial resistance patterns in Egypt.
机译：细菌病原体之间的抗菌使用及随后的耐药性是一个全球性问题，但在埃及，数据很少。骨科反映了这个问题，因为其中外科手术是主要的操作方式，败血病是常见的并发症，都需要指导性的抗菌治疗，否则就会出现抗菌素耐药性。为了突出这些问题，在埃及坦塔大学骨科进行了为期9个月的前瞻性研究，研究了分离微生物的抗菌药物使用和抗菌药敏模式。检出的抗生素处方率高（98.1％），适用率低（11.3％）。规定的抗菌剂的81％属于头孢菌素和青霉素类。术后继续进行抗生素预防（77％），感染（13.4％）以及随机（22％）。在大多数研究细菌中发现了高耐药性。 53.3％的金黄色葡萄球菌（S. aureus）和66.7％的凝固酶阴性葡萄球菌（CNS）分离株对奥沙西林耐药。多抗性菌株占分离的革兰氏阴性菌株的48.6％，其中ESBL（克雷伯菌62.5％和大肠杆菌33.3％）为29.2％，而MR假单胞菌和不动杆菌分离株为19.4％。我们骨科的抗生素治疗似乎很重要。需要增加和合理的努力来提高抗微生物治疗的适当性并最小化抗微生物剂耐药性的发展。我们还呼吁在全国范围内开展监测计划，以监测埃及的微生物趋势和抗菌素耐药性模式。

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