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首页> 外文期刊>International journal of immunopathology and pharmacology. >Effects and Degradable Mg-Nd-Zn-Zr Alloy on Osteoblastic Cell Function
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Effects and Degradable Mg-Nd-Zn-Zr Alloy on Osteoblastic Cell Function

机译:Mg-Nd-Zn-Zr合金及其降解对成骨细胞功能的影响

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This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferation, and mineralization were investigated using scanning electron microscopy (SEM), MTT assay and ambramycin staining, respectively. At the same time, the in vitro degradation behavior of the JDBM alloy in cell culture medium was evaluated by the weight-loss method and SEM. Pure magnesium was used as control. The results showed that osteoblastic cells cultured on JDBM alloy samples manifested better cell adhesion, improved cell proliferation and increased mineralization ability, compared with cells seeded on pure magnesium samples. Our data indicate that the JDBM alloy has excellent bioactivity, improving the cell function of osteoblastic cells seeded on it.
机译:这项研究旨在研究新型专利Mg-3Nd-0.2Zn-0.4Zr(重量%,JDBM)合金对成骨细胞功能的影响,因为这些细胞在骨修复和重塑中起重要作用。 JDBM合金对成骨细胞功能的相关影响涉及细胞粘附,细胞增殖和矿化作用,分别使用扫描电子显微镜(SEM),MTT分析和安布霉素染色进行了研究。同时,通过失重法和扫描电镜对JDBM合金在细胞培养基中的体外降解行为进行了评价。纯镁用作对照。结果表明,与接种在纯镁样品上的细胞相比,在JDBM合金样品上培养的成骨细胞表现出更好的细胞粘附性,改善的细胞增殖能力和增强的矿化能力。我们的数据表明,JDBM合金具有出色的生物活性,可改善接种在其上的成骨细胞的细胞功能。

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