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首页> 外文期刊>International Journal of Information Technology >Delivery of Positively Charged Proteins Using Hyaluronic Acid Microgels
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Delivery of Positively Charged Proteins Using Hyaluronic Acid Microgels

机译：使用透明质酸微凝胶输送带正电的蛋白质

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In this study, hyaluronic acid (HA) microgels were developed for the goal of protein delivery. First, a hyaluronic acid-tyramine conjugate (HA-TA) was synthesized with a degree of substitution of 13 TA moieties per 100 disaccharide units. Then, HA-TA microdroplets were produced using a water in oil emulsion method and crosslinked in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). Loading capacity and the release kinetics of lysozyme and BSA, as model proteins, were investigated. It was shown that lysozyme, a cationic protein, can be incorporated efficiently in the HA microgels, while the loading efficiency for BSA, as a negatively charged protein, is low. The release profile of lysozyme showed a sustained release over a period of one month. The results demonstrated that the HA-TA microgels are a good carrier for spatial delivery of cationic proteins for biomedical applications.
机译：在这项研究中，透明质酸（HA）微凝胶被开发用于蛋白质递送的目标。首先，合成透明质酸-酪胺缀合物（HA-TA），每100个二糖单元具有13个TA部分的取代度。然后，使用油包水乳液法制备HA-TA微滴，并在辣根过氧化物酶（HRP）和过氧化氢（H2O2）的存在下交联。研究了作为模型蛋白的溶菌酶和BSA的负载能力和释放动力学。结果表明，溶菌酶是一种阳离子蛋白，可以有效地掺入HA微凝胶中，而BSA作为带负电荷的蛋白的负载效率却很低。溶菌酶的释放曲线显示了一个月的持续释放。结果表明，HA-TA微凝胶是用于生物医学应用的阳离子蛋白空间递送的良好载体。

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