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首页> 外文期刊>International Journal of Gerontology >Analysis of Clinical Factors and Mortality in Diffuse Large B-cell Lymphoma Patients Over or Under 80 Years of Age
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Analysis of Clinical Factors and Mortality in Diffuse Large B-cell Lymphoma Patients Over or Under 80 Years of Age

机译：80岁以下未成年人弥漫性大B细胞淋巴瘤患者的临床因素和死亡率分析

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Summary Background The prognosis of diffuse large B-cell lymphoma (DLBCL) is remarkably improved after R-CHOP therapy. However, there are few detailed reports regarding very elderly DLBCL patients. We investigated relationships between prognostic factors and mortality risk in DLBCL patients, especially those aged 80 years or more. Methods The study subjects consisted of 141 patients newly-diagnosed with de novo DLBCL. Information regarding age, sex, stage, performance status (PS), lactate dehydrogenase (LDH), extranodal (EN) involvement, and therapies was available. Results For the 141 patients, the female sex was significantly inversely related to mortality, whereas age ≥80 years, PS ≥2, and non-standard therapy were significantly positively associated with death. No associations were observed between death and stage, LDH, or EN. When classifying patients by age ( Conclusion PS ≥2 may be positively associated with mortality, regardless of age. Female sex may be inversely related to mortality only in DLBCL patients aged 80 years or more, possibly due to the difference in rituximab clearance between the two study groups.
机译：发明背景R-CHOP治疗后弥漫性大B细胞淋巴瘤（DLBCL）的预后明显改善。但是，很少有关于非常老的DLBCL患者的详细报告。我们调查了DLBCL患者（尤其是80岁或以上的患者）的预后因素与死亡风险之间的关系。方法研究对象为141例新近诊断为新生DLBCL的患者。可获得有关年龄，性别，阶段，表现状态（PS），乳酸脱氢酶（LDH），结外（EN）感染和治疗的信息。结果141例患者中，女性与死亡率呈显着负相关，而年龄≥80岁，PS≥2和非标准疗法与死亡呈显着正相关。在死亡与阶段，LDH或EN之间未发现关联。在按年龄分类患者时（结论PS≥2可能与死亡率呈正相关，而与年龄无关。女性仅在80岁以上的DLBCL患者中可能与死亡率成反比，这可能是由于两者之间利妥昔单抗清除率的差异学习小组。

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