Coordination Chemistry of Polyaromatic Thiosemicarbazones 2: Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone

Marc-AndreLeBlanc; AntonioGonzalez-Sarrías; Floyd A.Beckford; P. CanisiusMbarushimana; Navindra P.Seeram

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Coordination Chemistry of Polyaromatic Thiosemicarbazones 2: Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone

机译：聚芳族硫代氨基脲的配位化学2：1-（萘-2-基）乙酮硫代氨基脲的锌，钴和铜配合物的合成及生物活性

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A novel thiosemicarbazone from 2-acetonaphthone (represented as acnTSC) has been synthesized and its basic coordination chemistry with zinc(II), cobalt(II), and copper(II) explored. The complexes were characterized by elemental analysis and various spectroscopic techniques and are best formulated as [M(acnTSC)2Cl2] with the metal likely in an octahedral environment. The anticancer activity of the complexes was determined against a panel of human colon cancer cells (HCT-116 and Caco-2). The compounds bind to DNA via an intercalative mode with binding constants of9.7×104 M-1,1.8×105 M-1, and9.5×104 M-1for the zinc, cobalt, and copper complexes, respectively.

机译：合成了一种新型的由2-乙酰萘酮（代表acnTSC）形成的硫半脲，并探讨了其与锌（II），钴（II）和铜（II）的基本配位化学。通过元素分析和各种光谱技术对络合物进行表征，最好用可能在八面体环境中的金属配制成[M（acnTSC）2Cl2]。确定了该复合物对一组人结肠癌细胞（HCT-116和Caco-2）的抗癌活性。这些化合物通过插入模式与DNA，锌和钴和铜配合物的结合常数分别为9.7×104 M-1、1.8×105 M-1和9.5×104 M-1结合到DNA。

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《International journal of inorganic chemistry: coordination chemistry》 |2011年第2期|共8页
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Marc-AndreLeBlanc; AntonioGonzalez-Sarrías; Floyd A.Beckford; P. CanisiusMbarushimana; Navindra P.Seeram;
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1. Coordination Chemistry of Polyaromatic Thiosemicarbazones 2: Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of l-(Naphthalene-2-yl)ethanone Thiosemicarbazone [J] . Marc-Andre LeBlanc, Antonio Gonzalez-Sarrias, Floyd A. Beckford International journal of inorganic chemistry: coordination chemistry . 2011,第2期

机译：聚芳香族硫代氨基脲的配位化学2：1-（萘-2-基）乙酮硫代氨基脲的锌，钴和铜配合物的合成及生物活性
2. Synthesis, crystal structure and biological activity of 1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone and its cobalt complex [J] . Poyraz M, Sari M, Demirci F, Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2008,第9a10期

机译：1-（1H-苯并咪唑-2-基）-乙酮硫半脲及其钴配合物的合成，晶体结构和生物活性
3. Synthesis, characterization and antibacterial activities of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes with soluble vitamin K_3 thiosemicarbazone [J] . Hui An Tang, Liu Fang Wang, Ru Dong Yang Transition Metal Chemistry . 2003,第4期

机译：锰（II），钴（II），镍（II），铜（II）和锌（II）与可溶性维生素K_3硫代半脲的配合物的合成，表征和抗菌活性
4. Spectral studies of copper(II) complexes of 6-(3-thienyl) pyridine-2-thiosemicarbazone [C] . Omima Abdalla Mahjoub, Yang Farina UKM FST Postgraduate Colloquium . 2014

机译：6-（3-噻吩基）吡啶-2-硫代噻吩的铜（II）复合物的光谱研究
5. Mode of action of copper complexes of thiosemicarbazones in human leukemia HL-60 cells. [D] . Durham, Richard Wayne, Jr. 2005

机译：硫半脲酮铜络合物在人白血病HL-60细胞中的作用方式。
6. Coordination Chemistry of Polyaromatic Thiosemicarbazones 2: Synthesis and Biological Activity of Zinc Cobalt and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone [O] . Marc-Andre LeBlanc, Antonio Gonzalez-Sarrías, Floyd A. Beckford, -1

机译：缩氨基硫脲多环芳烃的配位化学2：合成与锌钴的生物活性和1-铜配合物（萘-2-基）乙酮缩氨基硫脲
7. Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes [O] . K. Alomar, A. Landreau, M. Kempf, 2010

机译：合成，晶体结构，锌（II），镉（II）与3-噻吩醛缩氨基硫脲（3TTsCH）配合物的表征。 3TTsCH及其配合物的生物活性

Coordination Chemistry of Polyaromatic Thiosemicarbazones 2: Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone

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