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首页> 外文期刊>International Journal of Medical Sciences >The Association between the Phenotype of Excessive Daytime Sleepiness and Blood Pressure in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome
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The Association between the Phenotype of Excessive Daytime Sleepiness and Blood Pressure in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

机译：阻塞性睡眠呼吸暂停低通气综合征患者白天过度嗜睡的表型与血压之间的关系

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摘要

Objective Investigate the clinical features and the blood pressure (BP) pattern of the phenotype of excessive daytime sleepiness (EDS) in OSAHS. Methods A total of 508 Chinese adults with suspected OSAHS were referred to our sleep laboratory from October 2009 to May 2012. On the same night of polysomnography (PSG), the levels of blood pressure were measured before sleeping (bedtime BP) and immediately after waking up in the next morning (morning BP). EDS was recognized as Epworth Sleepiness Scale (ESS)≥9. Subjects were classified into four groups based on the apnea-hypopnea index (AHI) from PSG as follows: control (simple snoring) group (control, n=104) with AHIResults In all subjects, ESS was positively correlated with morning diastolic blood pressure (DBP), Mean arterial pressure (MAP) and bedtime DBP (r=0.144, 0.102 and 0.114, respectively, each P valueConclusions EDS in OSAHS patients is a special phenotype, which was characterized by younger age, higher DBP and more severe hypoxic load. This feature is mainly manifested in moderate and severe OSAHS patients. It is very important to identify the phenotype of EDS in patients with OSAHS, who may meet more benefits from effective treatment of OSAHS by correcting the intermittent nocturnal hypoxia and sleep fragmentation.
机译：目的研究OSAHS中白天过度嗜睡（EDS）表型的临床特征和血压（BP）模式。方法从2009年10月至2012年5月，将508名中国人中怀疑患有OSAHS的人转介到我们的睡眠实验室。在多导睡眠图检查（PSG）的同一天晚上，对睡眠前（就寝时间BP）和醒来后的血压水平进行了测量。在第二天早上起来（早上BP）。 EDS被认为是Epworth嗜睡量表（ESS）≥9。根据PSG的呼吸暂停-低通气指数（AHI）将受试者分为四组：对照组（单纯打ing）组（对照组，n = 104）和AHI结果在所有受试者中，ESS与早晨舒张压呈正相关（ DBP），平均动脉压（MAP）和就寝时间DBP（分别为r = 0.144、0.102和0.114，每个P值）结论OSAHS患者的EDS是一种特殊的表型，其特点是年龄较小，DBP较高且缺氧负荷更严重。此特征主要表现在中度和重度OSAHS患者中，对OSAHS患者的EDS表型的识别非常重要，他们可以通过纠正间歇性夜间缺氧和睡眠破碎来从OSAHS的有效治疗中受益更多。

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