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首页> 外文期刊>International Journal of Medical Sciences >Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas
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Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas

机译:组蛋白脱乙酰基酶(HDAC)指导T细胞淋巴瘤的新疗法

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T-cell lymphomas are a heterogeneous group of cancers with different pathogenesis and poor prognosis. Histone deacetylases (HDACs) are epigenetic modifiers that modulate many key biological processes. In recent years, HDACs have been fully investigated for their roles and potential as drug targets in T-cell lymphomas. In this review, we have deciphered the modes of action of HDACs, HDAC inhibitors as single agents, and HDACs guided combination therapies in T-cell lymphomas. The overview of HDACs on the stage of T-cell lymphomas, and HDACs guided therapies both as single agents and combination regimens endow great opportunities for the cure of T-cell lymphomas.
机译:T细胞淋巴瘤是一组异质性癌症,其发病机理不同且预后较差。组蛋白脱乙酰基酶(HDAC)是表观遗传修饰剂,可调节许多关键的生物学过程。近年来,已经对HDAC在T细胞淋巴瘤中作为药物靶标的作用和潜力进行了充分研究。在这篇综述中,我们已经破译了HDAC,HDAC抑制剂作为单一药物的作用方式,以及HDAC指导的T细胞淋巴瘤联合治疗。 HDAC在T细胞淋巴瘤阶段的概述,以及HDAC作为单一药物和联合治疗的指导疗法,为治愈T细胞淋巴瘤提供了巨大的机会。

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