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首页> 外文期刊>International Journal of Marine Science >Screening Twelve Species of Sponges for Biomedical Activity in Gulf of Mannar Tuticorin Coast
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Screening Twelve Species of Sponges for Biomedical Activity in Gulf of Mannar Tuticorin Coast

机译：在Mannar杜蒂戈林海岸的十二种海绵中进行生物医学活性筛选

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摘要

To screen the antibacterial efficacy of various solvent extracts of 12 species marine sponges against some selected bacteria and fungi human pathogenic bacteria. Crude extracts were prepared from the selected marine sponge using different solvents namely, ethyl acetate and methanol and were tested for their antibacterial activity against human pathogenic bacteria using disc diffusion method. Minimum inhibitory concentration (MIC) was also performed for selected solvent extracts for all the bacterial species. A suitable positive control was also maintained. Among the marine sponge 12 species screened were found to be more active than 2 sponges. It was observed that the ethyl acetate extracts of the marine sponge showed higher inhibitory activity for the selected bacterial species than methanol solvent extracts. The results revealed that the crude ethyl acetate extracts seem to be a good source material in identifying the effective pure antibacterial compound in the sponges. The present study showed that the ethyl acetate extracts of marine sponges such as exhibited good antimicrobial activity. But the ethyl acetate of Aurora globostellata (Carter) and Spirastrella inconstans var. moeandrina Dendy sponge possessed highest antibacterial activity than methanol extracts and so it could be useful in seeking active principles against human pathogenic bacteria.
机译：为了筛选12种海洋海绵的各种溶剂提取物对某些选定的细菌和真菌人类病原菌的抗菌效果。使用不同的溶剂（即乙酸乙酯和甲醇）从选定的海洋海绵中制备粗提取物，并使用圆盘扩散法测试其对人类病原菌的抗菌活性。还对所有细菌物种的选定溶剂提取物进行了最小抑菌浓度（MIC）。还维持合适的阳性对照。在海洋海绵中，筛选出的12种物种比2种海绵更具活性。观察到，海洋海绵的乙酸乙酯提取物对选定细菌的抑制活性高于甲醇溶剂提取物。结果表明，乙酸乙酯粗提物似乎是鉴定海绵中有效的纯抗菌化合物的良好来源。本研究表明，诸如海事海绵的乙酸乙酯提取物表现出良好的抗菌活性。但是球状极光（Carter）和常量螺旋藻的乙酸乙酯。 moeandrina Dendy海绵比甲醇提取物具有最高的抗菌活性，因此可用于寻找对抗人类病原菌的有效成分。

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