Heatstroke Effect on Brain Heme Oxygenase-1 in Rats

Ya-Ting Wen; Tsung-Ta Liu; Yuh-Feng Lin; Chun-Chi Chen; Woon-Man Kung; Chi-Chang Huang; Tien-Jen Lin; Yuan-Hung Wang; Li Wei

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Heatstroke Effect on Brain Heme Oxygenase-1 in Rats

机译：中暑对大鼠脑血红素加氧酶-1的影响

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Exposure to high environmental temperature leading to increased core body temperature above 40°C and central nervous system abnormalities such as convulsions, delirium, or coma is defined as heat stroke. Studies in humans and animals indicate that the heat shock responses of the host contribute to multiple organ injury and death during heat stroke. Heme oxygenase-1 (HO-1)—a stress-responsive enzyme that catabolizes heme into iron, carbon monoxide, and biliverdin—has an important role in the neuroprotective mechanism against ischemic stroke. Here, we investigated the role of endogenous HO-1 in heat-induced brain damage in rats. RT-PCR results revealed that levels of HO-1 mRNA peaked at 0 h after heat exposure and immunoblot analysis revealed that the maximal protein expression occurred at 1 h post-heat exposure. Subsequently, we detected the HO-1 expression in the cortical brain cells and revealed the neuronal cell morphology. In conclusion, HO-1 is a potent protective molecule against heat-induced brain damage. Manipulation of HO-1 may provide a potential therapeutic approach for heat-related diseases.

机译：暴露于高环境温度下会导致核心体温升高到40°C以上，中枢神经系统异常（例如抽搐，del妄或昏迷）被定义为中暑。对人类和动物的研究表明，宿主的热休克反应会导致中暑期间多器官损伤和死亡。血红素加氧酶-1（HO-1）是一种应激反应酶，可将血红素分解为铁，一氧化碳和胆绿素。它在针对缺血性中风的神经保护机制中具有重要作用。在这里，我们调查了内源性HO-1在大鼠热诱导的脑损伤中的作用。 RT-PCR结果显示HO-1 mRNA水平在热暴露后0 h达到峰值，免疫印迹分析显示最大蛋白表达发生在热暴露后1 h。随后，我们检测了皮质脑细胞中HO-1的表达，并揭示了神经元细胞的形态。总之，HO-1是一种有效的保护分子，可防止热诱导的脑损伤。 HO-1的操作可能为热相关疾病提供潜在的治疗方法。

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《International Journal of Medical Sciences》 |2015年第9期|共5页
作者
Ya-Ting Wen; Tsung-Ta Liu; Yuh-Feng Lin; Chun-Chi Chen; Woon-Man Kung; Chi-Chang Huang; Tien-Jen Lin; Yuan-Hung Wang; Li Wei;
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中图分类医药、卫生;
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1. Expression of heme oxygenase-1 in type II pneumocytes protects against heatstroke-induced lung damage [J] . Chin-Kun Tseng, Tsung-Ta Liu, Tsung-Chieh Lin, Cell stress & chaperones . 2021,第1期

机译：II型肺炎血细胞中血红素氧合酶-1的表达可防止中暑诱导的肺部损伤
2. Selective brain cooling in rats ameliorates intracerebral hemorrhage and edema caused by penetrating brain injury: possible involvement of heme oxygenase-1 expression. [J] . Yao C, Wei G, Lu XC, Journal of neurotrauma . 2011,第7期

机译：大鼠的选择性脑冷却可改善由穿透性脑损伤引起的脑出血和水肿：血红素加氧酶-1表达可能参与。
3. Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain. [J] . Geddes JW, Pettigrew LC, Holtz ML, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1996,第3期

机译：永久性局灶性和短暂性全脑缺血可增加大鼠脑中血红素加氧酶-1（而非血红素加氧酶-2）蛋白的神经胶质和神经元表达。
4. Sensitive heme sensor using fluorescent-labeled heme oxygenase-1 [C] . Shinya Koga, Yuichiro Higashimoto, Masato Noguchi Japanese peptide symposium . 2011

机译：敏感血红素传感器使用荧光标记的血红素氧酶-1
5. Mechanisms of heme oxygenase-1 gene regulation by heme-hemopexin. [D] . Rish, Kimberly Renee. 2004

机译：血红素-hemopexin调节血红素加氧酶-1基因的机制。
6. Heatstroke Effect on Brain Heme Oxygenase-1 in Rats [O] . Ya-Ting Wen, Tsung-Ta Liu, Yuh-Feng Lin, 2015

机译：中暑对大鼠脑血红素加氧酶-1的影响
7. Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1 [O] . Yong Son, Ju Hwan Lee, Hun-Taeg Chung, 2013

机译：血红素氧合酶-1在代谢疾病中的治疗作用：姜黄素和白藜芦醇类似物，作为血红素氧酶-1可能的诱导剂

Heatstroke Effect on Brain Heme Oxygenase-1 in Rats

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