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首页> 外文期刊>International Journal of Medical Sciences >Association study of polymorphisms in miRNAs with T2DM in Chinese population
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Association study of polymorphisms in miRNAs with T2DM in Chinese population

机译：中国人群miRNA与T2DM多态性的关联研究

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Accumulated evidence indicates that microRNA (miRNA or miR) is involved in the development of type 2 diabetes (T2DM). Several studies have shown that single nucleotide polymorphisms (SNPs) located in miRNAs are associated with T2DM in Caucasian populations. The association studies of miRNA's SNPs with T2DM in Asian are rarely reported, and there are distinct genetic differences between Caucasian and Asian populations. The focus of this study, therefore, is the association of T2DM with five SNPs (rs895819 in miR-27a, rs531564 in miR-124a, rs11888095 in miR-128a, rs3820455 in miR-194a and rs2910164 in miR-146a) located in five miRNAs in a Han Chinese population. A total of 738 subjects with T2DM and 610 non-diabetic subjects were genotyped using the TaqMan method. Next, the associations between the five SNPs with T2DM and individual metabolic traits were evaluated. Our data showed that the C allele of rs531564 in miR-124a may protect against T2DM (P=0.009, OR=0.758; 95%CI: 0.616-0.933). Conversely, the C allele of rs2910164 in miR-146a may increase the risk of developing T2DM (P<0.001, OR=1.459; 95%CI: 1.244-1.712). However, these five SNPs did not exhibit significant associations with individual metabolic traits in either the T2DM or non-diabetic groups. Our results revealed that genetic variations in miRNAs were associated with T2DM susceptibility in a Han Chinese population, and these results highlight the need to study the functional effects of these variants in miRNAs on the risk of developing T2DM.
机译：积累的证据表明，microRNA（miRNA或miR）参与了2型糖尿病（T2DM）的发展。多项研究表明，位于miRNA中的单核苷酸多态性（SNP）与高加索人群的T2DM相关。在亚洲很少报道miRNA的SNP与T2DM的关联性研究，白种人和亚洲人群之间存在明显的遗传差异。因此，本研究的重点是T2DM与位于五个区域的五个SNP（miR-27a中的rs895819，miR-124a中的rs531564，miR-128a中的rs11888095，miR-194a中的rs3820455和miR-146a中的rs2910164）相关联。汉族人群中的miRNA。使用TaqMan方法对738名T2DM受试者和610名非糖尿病受试者进行了基因分型。接下来，评估了具有S2DM的五个SNP与个体代谢性状之间的关联。我们的数据显示，miR-124a中rs531564的C等位基因可能对T2DM具有保护作用（P = 0.009，OR = 0.758; 95％CI：0.616-0.933）。相反，miR-146a中rs2910164的C等位基因可能会增加患上T2DM的风险（P <0.001，OR = 1.459; 95％CI：1.244-1.712）。然而，这两种SNP在T2DM或非糖尿病组中均未显示出与个体代谢性状的显着相关性。我们的结果表明，在汉族人群中，miRNA的遗传变异与T2DM易感性有关，这些结果凸显了研究miRNA中这些变异对发展T2DM风险的功能性影响的必要性。

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