...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review
【24h】

Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review

机译：血管紧张素转换酶基因插入/缺失多态性在健康和疾病中的意义：综述

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This review considers the 250+ papers concerning the association of the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (rs1799752) and various disease conditions published in 2009. The deletion allele occurs in approximately 55% of the population and is associated with increased activity of the ACE enzyme. It might be predicted that the D allele, therefore, might be associated with pathologies involving increased activity of the renin-angiotensin system. The D allele was seen to be associated with an increased risk of hypertension, pre-eclampsia, heart failure, cerebral infarct, diabetic nephropathy, encephalopathy, asthma, severe hypoglycaemia in diabetes, gastric cancer (in Caucasians) and poor prognosis following kidney transplant. On the positive side, the D allele appears to offer protection against schizophrenia and chronic periodontitis and confers greater up-per-body strength in old age. The I allele, meanwhile, offers improved endurance/athletic performance and aerobic capacity as determined by lung function tests, although it does increase the risk of oral squamous cell carcinoma and obstructive sleep apnoea in hypertensives.
机译：这篇综述考虑了250篇有关血管紧张素转换酶（ACE）基因插入/缺失多态性（rs1799752）与2009年发表的各种疾病状况的关联的论文。缺失等位基因出现在大约55％的人口中，并且与增加等位基因有关ACE酶的活性。因此，可以预测D等位基因可能与涉及肾素-血管紧张素系统活性增加的病理相关。 D等位基因被认为与高血压，先兆子痫，心力衰竭，脑梗塞，糖尿病肾病，脑病，哮喘，糖尿病，血糖低下，胃癌（白种人）和肾移植后预后不良的风险增加有关。从积极的方面来看，D等位基因似乎可以提供针对精神分裂症和慢性牙周炎的保护作用，并赋予老年人更高的上身力量。同时，I等位基因可提高肺功能测试所确定的耐力/运动能力和有氧能力，尽管它确实增加了高血压患者口腔鳞状细胞癌和阻塞性睡眠呼吸暂停的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号