• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of molecular imaging >Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma: A Step towards Personalized Care
【24h】

Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma: A Step towards Personalized Care

机译：回顾淋巴瘤化疗后的骨髓代谢变化：迈向个性化护理的一步

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose. The aims were to correlate individual marrow metabolic changes after chemotherapy with bone marrow biopsy (BMBx) for its potential value of personalized care in lymphoma.Methods. 26 patients (mean age, 58 ± 15 y; 13 female, 13 male) with follicular lymphoma or diffuse large B-cell lymphoma, referred to FDG-PET/CT imaging, who had BMBx from unilateral or bilateral iliac crest(s) before chemotherapy, were studied retrospectively. The maximal standardized uptake value (SUV) was measured from BMBx site over the same area on both initial staging and first available restaging FDG-PET/CT scan.Results. 35 BMBx sites in 26 patients were evaluated. 12 of 35 sites were BMBx positive with interval decrease in SUV in 11 of 12 sites (92%). The remaining 23 of 35 sites were BMBx negative with interval increase in SUV in 21 of 23 sites (91%). The correlation between SUV change over the BMBx site before and after chemotherapy and BMBx result was significant (P<0.0001).Conclusions. This preliminary result demonstrates a strong correlation between marrow metabolic changes (as determined by FDG PET) after chemotherapy and bone marrow involvement proven by biopsy. This may provide a retrospective means of personalized management of marrow involvement in deciding whether to deliver more extended therapy or closer followup of lymphoma patients.
机译：目的。目的是将化疗后个体骨髓代谢变化与骨髓活检（BMBx）相关联，以了解其个性化护理在淋巴瘤中的潜在价值。 26例滤泡性淋巴瘤或弥漫性大B细胞淋巴瘤（平均年龄58±15岁）; 13例女性，13例男性，经FDG-PET / CT显像，之前曾单侧或双侧c部出现BMBx化疗，进行了回顾性研究。在FDG-PET / CT扫描的初次分期和首次分期进行时，在同一区域的BMBx部位测量了最大标准化摄取值（SUV）。对26例患者的35个BMBx部位进行了评估。 35个站点中的12个站点的BMBx阳性，其中12个站点中的11个站点的SUV间隔减小（92％）。 35个站点中的其余23个站点的BMBx阴性，其中23个站点中的21个站点的SUV间隔增加（91％）。化疗前后BMBx部位的SUV变化与BMBx结果之间的相关性显着（P <0.0001）。该初步结果表明，化疗后骨髓代谢变化（由FDG PET确定）与活检证实的骨髓受累之间具有很强的相关性。这可以提供一种回顾性的骨髓参与个性化管理方法，以决定是否提供更多的延长治疗或更近距离的淋巴瘤患者随访。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号