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首页> 外文期刊>International journal of molecular imaging >The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification
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The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification

机译：基于CT的衰减校正和准直器模糊校正在纹状体斑点定量中的作用

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Purpose. Striatal single photon emission computed tomography (SPECT) imaging of the dopaminergic system is becoming increasingly used for clinical and research studies. The question about the value of nonuniform attenuation correction has become more relevant with the increasing availability of hybrid SPECT-CT scanners. In this study, the value of nonuniform attenuation correction and correction for collimator blurring were determined using both phantom data and patient data.Methods. SPECT imaging was performed using 7 anthropomorphic phantom measurements, and 14 patient studies using [I-123]-FP-CIT (DATSCAN). SPECT reconstruction was performed using uniform and nonuniform attenuation correction and collimator blurring corrections. Recovery values (phantom data) or average-specific uptake ratios (patient data) for the different reconstructions were compared at similar noise levels.Results. For the phantom data, improved recovery was found with nonuniform attenuation correction and collimator blurring corrections, with further improvement when performed together. However, for patient data the highest average specific uptake ratio was obtained using collimator blurring correction without nonuniform attenuation correction, probably due to subtle SPECT-CT misregistration.Conclusions. This study suggests that an optimal brain SPECT reconstruction (in terms of the lowest bias) in patients would include a correction for collimator blurring and uniform attenuation correction.
机译：目的。多巴胺能系统的纹状体单光子发射计算机断层扫描（SPECT）成像正越来越多地用于临床和研究。随着混合SPECT-CT扫描仪可用性的提高，关于非均匀衰减校正值的问题变得越来越重要。在这项研究中，使用幻像数据和患者数据确定了非均匀衰减校正值和准直仪模糊校正值。使用7种拟人化体模测量进行SPECT成像，并使用[I-123] -FP-CIT（DATSCAN）进行14项患者研究。使用均匀和非均匀衰减校正和准直仪模糊校正执行SPECT重建。在相似的噪声水平下比较了不同重建物的恢复值（幻像数据）或平均特异性摄取率（患者数据）。对于体模数据，发现使用不均匀的衰减校正和准直器模糊校正可以改善恢复，并一起执行时可以进一步改善。但是，对于患者数据，使用准直器模糊校正而不进行不均匀的衰减校正可获得最高的平均比摄取率，这可能是由于SPECT-CT配准错误引起的。这项研究表明，患者的最佳脑部SPECT重建（就最低偏差而言）将包括准直器模糊校正和均匀衰减校正。

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