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首页> 外文期刊>International journal of molecular imaging >TC-99m HMPAO Brain Blood Flow Imaging in the Dementias with Histopathologic Correlation in 73 Patients
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TC-99m HMPAO Brain Blood Flow Imaging in the Dementias with Histopathologic Correlation in 73 Patients

机译：TC-99m痴呆患者脑血流成像与组织病理学相关性的73例患者

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摘要

The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias. Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Images were further processed using Statistical Parametric Mapping. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 73 subjects were compared with a neuropathologic study of the brain at autopsy. Data were analyzed for sensitivity, specificity, positive and negative predictive values and accuracy. These results are compared with several other studies performed with Tc-99m HMPAO SPECT with histopathologic correlation. This procedure is widely available and relatively inexpensive and may be of value in patients with dementias and problematic diagnoses. Further, a degree of differential diagnosis between Alzheimer's and Frontotemporal diseases may be effected. The study was approved by our Institutional Review Board.
机译：这项研究的目的是确定Tc-99m HMPAO SPECT在痴呆诊断中的价值。 Tc-99m HMPAO与3台照相机扫描仪一起使用，以产生5组大脑断层图像。使用统计参数映射对图像进行进一步处理。诊断由对临床诊断不了解的医生进行。将73名受试者的结果与尸体解剖时大脑的神经病理学研究进行了比较。分析数据的敏感性，特异性，阳性和阴性预测值以及准确性。将这些结果与其他Tc-99m HMPAO SPECT具有组织病理学相关性的研究进行了比较。该方法是广泛可用的并且相对便宜，并且对于痴呆和诊断有问题的患者可能是有价值的。此外，在阿尔茨海默氏病和额颞部疾病之间可以进行一定程度的鉴别诊断。该研究已获得我们机构审查委员会的批准。

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