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首页> 外文期刊>Radiology >Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients.
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Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients.

机译：痴呆症的脑血流量：SPECT与54例患者的组织病理学相关性。

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PURPOSE: To evaluate single photon emission computed tomographic (SPECT) imaging of regional cerebral blood flow in the diagnosis of Alzheimer disease (AD) and the differential diagnosis of the dementias. MATERIALS AND METHODS: Regional cerebral blood flow SPECT was performed with inhaled xenon-133 in 261 patients and with injected technetium-99m hexamethyl-propyleneamine oxime (HMPAO) in 162 patients with possible dementia. In 16 patients, both agents were used in 1 day. SPECT images obtained in elderly healthy control subjects (with Xe-133 in 15, with Tc-99m HMPAO in 14) were available. In each patient without AD, further classification of disease was attempted. Histopathologic correlation was available in 54 patients (with autopsy in 51, with biopsy in three). RESULTS: SPECT diagnoses were true-positive in 37, true-negative in eight, false-positive in three, and false-negative in six patients. Sensitivity was 86% (37 of 43; 95% confidence limits = .72, .95); specificity, 73% (eight of 11; confidencelimits = .39, .94); positive predictive value, 92% (37 of 40; confidence limits = .80, .98); and negative predictive value, 57% (eight of 14; confidence limits = .29, .82). CONCLUSION: Regional cerebral blood flow SPECT may assist in the early and late diagnoses of AD and in the differential-diagnosis of the dementias when there is a complicated or confusing clinical picture.
机译：目的：评估局部脑血流的单光子发射计算机断层扫描（SPECT）成像，以诊断阿尔茨海默病（AD）和痴呆症的鉴别诊断。材料与方法：261例患者使用氙133吸入，162例可能的痴呆患者用injected 99m六甲基-丙胺肟（HMPAO）注射进行局部脑血流SPECT检测。在16例患者中，两种药物均在1天之内使用。可获取在老年健康对照受试者中获得的SPECT图像（Xe-133为15，Tc-99m HMPAO为14）。在没有AD的每位患者中，尝试了进一步的疾病分类。 54例患者具有组织病理学相关性（51例进行尸检，三例进行活检）。结果：SPECT诊断为真阳性37例，真阴性8例，假阳性3例，假阴性6例。敏感度为86％（43中的37; 95％置信度= 0.72，.95）;特异性73％（11个中的8个;置信度= 0.39，.94）;阳性预测值92％（40中的37;置信度= .80，.98）;阴性预测值为57％（14个中的8个;置信度= 0.29，.82）。结论：当临床情况复杂或令人困惑时，局部脑血流SPECT可能有助于AD的早期和晚期诊断以及痴呆的鉴别诊断。

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