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首页> 外文期刊>International journal of molecular imaging >The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II
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The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II

机译：PET和氨基酸示踪剂在世界卫生组织Ⅱ级胶质瘤中的临床价值

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The clinical management of adults with low-grade gliomas (LGGs) remains a challenge. There is no curative treatment, and management of individual patients is a matter of deciding optimal timing as well as right treatment modality. In addition to conventional imaging techniques, positron emission tomography (PET) with amino acid tracers can facilitate diagnostic and therapeutic procedures. In this paper, the clinical applications of PET with amino acid tracers11C-methyl-L-methionine (MET) and18F-fluoro-ethyl-L-tyrosine (FET) for patients with LGG are summarized. We also discuss the value of PET for the long-term followup of this patient group. Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors. As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.
机译：成人低度神经胶质瘤（LGG）的临床管理仍然是一个挑战。没有治愈性的治疗方法，单个患者的治疗是决定最佳时机和正确治疗方式的问题。除了常规的成像技术外，带有氨基酸示踪剂的正电子发射断层扫描（PET）可以促进诊断和治疗程序。本文总结了伴有氨基酸示踪剂的11C-甲基-L-蛋氨酸（MET）和18F-氟乙基-L-酪氨酸（FET）在PET中的临床应用。我们还讨论了PET在该患者组的长期随访中的价值。在病程中通过PET监测个别患者的代谢活性将提供有关这些肿瘤的生物学行为和进化的见识。这样，随着时间的推移，肿瘤活动的空间变化，包括肿瘤内热点区域的移动，可能反映出肿瘤内的异质性并与临床参数相关。

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