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首页> 外文期刊>The Journal of Nuclear Medicine >Comparison of the amino acid tracers 18F-FET and 18F-DOPA in high-grade glioma patients
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Comparison of the amino acid tracers 18F-FET and 18F-DOPA in high-grade glioma patients

机译：高度脑胶质瘤患者氨基酸示踪剂18F-FET和18F-DOPA的比较

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Results: Visual analysis revealed no difference in tumor uptake pattern between the 2 PET probes. The SUVmean and SUVmax for 18F-FET were higher than those of 18F-DOPA (4.0 ± 2.0 and 4.9 ± 2.3 vs. 3.5 ± 1.6 and 4.3 ± 2.0, respectively; all P 0.001). TBRs for SUVmean but not for SUVmax were significantly higher for 18F-FET than 18F-DOPA (TBR SUVmean: 3.8 ± 1.7 vs. 3.4 ± 1.2, P = 0.004; TBR SUVmax: 3.3 ± 1.6 and 3.0 ± 1.1, respectively; P = 0.086). 18FDOPA uptake by the basal ganglia was present (SUVmean, 2.6 ± 0.7) but did not affect tumor visualization.Methods: Thirty 18F-FET and 18F-DOPA PET/CT scans were obtained before surgery or biopsy in 27 patients with high clinical suspicion for primary or recurrent HGG (5 primary, 22 recurrent tumors). 18F-FET and 18F-DOPA PET/CT images were compared visually and semi-quantitatively (maximum standardized uptake value [SUVmax], mean SUV [SUVmean]). Background (SUVmax and SUVmean) and tumor-to-background ratios (TBRs) were calculated for both PET probes. The degree of 18F-DOPA uptake in the basal ganglia (SUVmean) was also assessed.Conclusion: Whereas visual analysis revealed no significant differences in uptake pattern for 18F-FET and 18F-DOPA in patients with primary or recurrent HGG, both SUVs and TBRs for SUVmean were significantly higher for 18F-FET. However, regarding tumor delineation, both tracers performed equally well and seem equally feasible for imaging of primary and recurrent HGG. These findings suggest that both PET probes can be used based on availability in multicenter trials.High-grade gliomas (HGGs) are the most common malignant primary tumors of the central nervous system. PET probes of amino acid transport such as O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET), 3,4- dihydroxy-6-18F-fluoro-L-phenylalanine (18F-DOPA), and 11C-methionine (11C-MET) detect primary and recurrent tumors with a high accuracy. 18F-FET is predominantly used in Europe, whereas amino acid transport imaging is infrequently done in the United States. The aim of this study was to determine whether 18F-FET and 18F-DOPA PET/CT provide comparable information in HGG.
机译：结果：视觉分析显示两种PET探针之间的肿瘤摄取模式没有差异。 18F-FET的SUVmean和SUVmax高于18F-DOPA（分别为4.0±2.0和4.9±2.3与3.5±1.6和4.3±2.0;所有P <0.001）。 SUVmean的TBRs而非SUVmax的TBR显着高于18F-DOPA（TBR SUVmean：3.8±1.7与3.4±1.2，P = 0.004; TBR SUVmax：分别为3.3±1.6和3.0±1.1; P = 0.086）。存在基底节18FDOPA的摄取（SUVmean，2.6±0.7），但不影响肿瘤的可视化方法。方法：对27例临床上高度怀疑其的患者进行手术或活检前进行了30次18F-FET和18F-DOPA PET / CT扫描。原发性或复发性HGG（5个原发性，22个复发性肿瘤）。目视和半定量比较18F-FET和18F-DOPA PET / CT图像（最大标准摄取值[SUVmax]，平均SUV [SUVmean]）。计算两种PET探针的背景（SUVmax和SUVmean）和肿瘤与背景之比（TBR）。结论：视力分析显示，原发性或复发性HGG，SUVs和TBRs患者的18F-FET和18F-DOPA摄取模式无显着差异，而对基础神经节（SUVmean）的摄取也进行了评估。 SUVmean的平均值明显高于18F-FET。但是，关于肿瘤的轮廓，两种示踪剂的表现均相当好，对于原发性和复发性HGG的成像似乎同样可行。这些发现表明，基于多中心试验的可用性，两种PET探针都可以使用。高级神经胶质瘤（HGG）是中枢神经系统最常见的恶性原发肿瘤。氨基酸转运的PET探针，例如O-（2-18F-氟乙基）-L-酪氨酸（18F-FET），3,4-二羟基-6-18F-氟-L-苯丙氨酸（18F-DOPA）和11C -蛋氨酸（11C-MET）可以高精度检测原发性和复发性肿瘤。在欧洲主要使用18F-FET，而在美国很少进行氨基酸转运成像。这项研究的目的是确定18F-FET和18F-DOPA PET / CT是否在HGG中提供可比的信息。

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