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SPECT Imaging of Epilepsy: An Overview and Comparison with F-18 FDG PET

机译：癫痫的SPECT成像：与F-18 FDG PET的概述和比较

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Epilepsy surgery is highly effective in treating refractoryepilepsy, but requires accurate presurgical localization of theepileptogenic focus. Briefly, localization of the region ofseizure onset traditionally dependents on seizure semiology, scalpEEG recordings and correlation with anatomical imaging modalitiessuch as MRI. The introduction of noninvasive functionalneuroimaging methods, including single-photon emission computedtomography (SPECT) and positron emission tomography (PET) hasdramatically changed the method for presurgical epilepsyevaluation. These imaging modalities have become powerful toolsfor the investigation of brain function and are an essential partof the evaluation of epileptic patients. Of these methods, SPECThas the practical capacity to image blood flow functional changesthat occur during seizures in the routine clinical setting. Inthis review we present the basic principles of epilepsy SPECT andPET imaging. We discuss the properties of the SPECT tracers to beused for this purpose and imaging acquisition protocols as well asthe diagnostic performance of SPECT in addition to SPECT imageanalysis methods. This is followed by a discussion and comparisonto F-18 FDG PET acquisition and imaging analysis methods.
机译：癫痫手术在治疗难治性癫痫方面非常有效，但需要精确的术前定位来确定癫痫病灶。简而言之，癫痫发作区域的定位传统上取决于癫痫发作的符号学，头皮脑电图记录以及与诸如MRI之类的解剖学成像方式的相关性。引入无创功能性神经成像方法，包括单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET），极大地改变了术前癫痫评估方法。这些成像方式已成为研究脑功能的强大工具，并且是评估癫痫患者的重要组成部分。在这些方法中，SPECT具有对常规临床环境中癫痫发作期间发生的血流功能变化进行成像的实用能力。在这篇综述中，我们介绍了癫痫的SPECT和PET成像的基本原理。除了SPECT图像分析方法外，我们还将讨论用于此目的的SPECT示踪剂的性质和成像采集协议以及SPECT的诊断性能。接下来是对F-18 FDG PET采集和成像分析方法的讨论和比较。

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