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首页> 外文期刊>International journal of molecular imaging >64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and IntegrinαVβ3Expression in Human Neuroendocrine Tumor Xenografts
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64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and IntegrinαVβ3Expression in Human Neuroendocrine Tumor Xenografts

机译：64Cu-NODAGA-c（RGDyK）是一种有前途的新型血管生成PET示踪剂：人神经内分泌肿瘤异种移植物中肿瘤摄取与整联蛋白αVβ3表达之间的相关性。

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Purpose. The purpose of this paper is to evaluate a new PET tracer64Cu-NODAGA-c(RGDyK) for imaging of tumor angiogenesis using gene expression of angiogenesis markers as reference and to estimate radiation dosimetry for humans.Procedures. Nude mice with human neuroendocrine tumor xenografts (H727) were administered64Cu-NODAGA-c(RGDyK) i.v. for study of biodistribution as well as for dynamic PET. Gene expression of angiogenesis markers integrinαV, integrinβ3, and VEGF-A were analyzed using QPCR and correlated to the tracer uptake in the tumors (%ID/g). From biodistribution data human radiation-absorbed doses were estimated using OLINDA/EXM.Results. Tumor uptake was 1.2%ID/g with strong correlations between gene expression and tracer uptake, for integrinαV R=0.76, integrinβ3 R=0.75and VEGF-AR=0.81(allP<0.05). The whole body effective dose for humans was estimated to be 0.038 and 0.029 mSv/MBq for females and males, respectively, with highest absorbed dose in bladder wall.Conclusion.64Cu-NODAGA-c(RGDyK) is a promising new angiogenesis PET tracer with potential for human use.
机译：目的。本文的目的是评估一种新的PET示踪剂64Cu-NODAGA-c（RGDyK），以血管生成标记物的基因表达为参考，用于肿瘤血管生成的成像，并评估人类的放射剂量。将具有人神经内分泌肿瘤异种移植物（H727）的裸鼠静脉注射64 Cu-NODAGA-c（RGDyK）。用于研究生物分布以及动态PET。使用QPCR分析血管生成标记整合素αV，整合素β3和VEGF-A的基因表达，并与肿瘤中示踪剂的摄取相关（％ID / g）。根据生物分布数据，使用OLINDA / EXM估算了人体辐射吸收剂量。对于整联蛋白αVR = 0.76，整联蛋白β3R = 0.75和VEGF-AR = 0.81，肿瘤的摄取率为1.2％ID / g，与基因表达和示踪剂摄取之间有很强的相关性。据估计，人的全身有效剂量分别为0.038和0.029 mSv / MBq，对男性和女性而言，在膀胱壁的吸收剂量最高。结论64Cu-NODAGA-c（RGDyK）是一种有希望的新型血管生成PET示踪剂，具有供人类使用的潜力。

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