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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Gamma-glutamyl transferase and C-reactive protein as alternative markers of metabolic abnormalities and their associated comorbidites: a prospective cohort study
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Gamma-glutamyl transferase and C-reactive protein as alternative markers of metabolic abnormalities and their associated comorbidites: a prospective cohort study

机译：γ-谷氨酰转移酶和C反应蛋白作为代谢异常及其相关合并症的替代标记：一项前瞻性队列研究

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Background: Recent studies suggested that gamma-glutamyl transferase (GGT) and C-reactive protein (CRP) are good markers of metabolic abnormalities. We assessed the link between GGT, CRP and common metabolic abnormalities, as well their link to related diseases, such as cancer and cardiovascular disease (CVD). Methods: We selected 333,313 subjects with baseline measurements of triglycerides (TG), total cholesterol (TC), glucose, GGT and CRP in the Swedish AMORIS study. Baseline measurement of BMI was available for 63,900 persons and 77,944 had baseline measurements of HDL. Pearson correlation coefficients between CRP, GGT, and metabolic components (TG, HDL, BMI and TC) were calculated. To investigate the combined effect of GGT and CRP we created a score ranging from 0 to 6 and used Cox proportional hazard models to evaluate its association with CVD and cancer. Results: 21,216 individuals developed cancer and 47,939 CVD. GGT and TG had the strongest correlation (r=0.22). An increased risk of cancer was identified with elevated levels of GGT or CRP or both markers (GGT-CRP score ≥3); the greatest risk of cancer was found when GGT-CRP score = 6 (HR: 1.40 (95%CI: 1.31-1.48) and 1.60 (1.47-1.76) compared to GGT-CRP score = 0, respectively). Conclusion: While GGT and CRP have been shown to be associated with metabolic abnormalities previously, their association to the components investigated in this study was limited. Results did demonstrate that these markers were predictive of associated diseases, such as cancer.
机译：背景：最近的研究表明，γ-谷氨酰转移酶（GGT）和C反应蛋白（CRP）是代谢异常的良好标志。我们评估了GGT，CRP和常见代谢异常之间的联系，以及它们与相关疾病（如癌症和心血管疾病（CVD））的联系。方法：在瑞典AMORIS研究中，我们选择了333,313名受试者进行了甘油三酸酯（TG），总胆固醇（TC），葡萄糖，GGT和CRP基线测量。可以对63,900人进行BMI的基线测量，对HDL进行基线测量的有77,944人。计算CRP，GGT和代谢成分（TG，HDL，BMI和TC）之间的皮尔逊相关系数。为了研究GGT和CRP的综合作用，我们创建了一个介于0到6之间的评分，并使用Cox比例风险模型评估了其与CVD和癌症的关系。结果：21,216个人患了癌症，47,939 CVD。 GGT和TG具有最强的相关性（r = 0.22）。升高的GGT或CRP或两种标志物的水平（GGT-CRP评分≥3）可确定患癌的风险增加;当GGT-CRP得分= 0时，GGT-CRP得分= 6（HR：1.40（95％CI：1.31-1.48）和1.60（1.47-1.76）），发现最大的癌症风险。结论：虽然先前已证明GGT和CRP与代谢异常有关，但它们与本研究中研究的成分的关联是有限的。结果确实表明这些标记物可预测相关疾病，例如癌症。

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