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首页> 外文期刊>Diabetes & metabolic syndrome. >Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: A prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS)
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Role of gamma-glutamyl transferase (GGT) in diagnosis of impaired glucose tolerance and metabolic syndrome: A prospective cohort research from the Kerman Coronary Artery Disease Risk Study (KERCADRS)

机译：γ-谷氨酰转移酶（GGT）在糖耐量减低和代谢综合征诊断中的作用：克曼冠状动脉疾病风险研究（KERCADRS）的前瞻性队列研究

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Aims: The important role of raised serum gamma-glutamyl transferase (GGT) for predicting diabetesmellitus and insulin resistance is clear; however relationship between increased level of GGT andimpaired glucose tolerance (IGT) is now hypothesized. We aimed to show the importance of GGTmeasurement in diagnosis of IGT. Materials and methods: Two hundred persons were randomly selected from the Kerman Coronary ArteryDisease Risk Study (KERCADRS), as a population-based study. All participants underwent GGT analysistest, besides measuring risk factors and components of metabolic syndrome (MS).Results: The increase in GGT was correlated with increased prevalence of IGT and MS and its differentcomponents. In multivariable analysis, a high GGT was positively associated with the presence of IGTafter adjustment for age, sex and MS diagnostic criteria. The area under curve (AUC) for GGT was 0.722 fordiscriminating IGT from normal condition, and 0.847 for discriminating MS from normal status. In ROCcurve analysis, the optimal cut-off value for GGT to discriminate IGT from normal condition was 20.5 IUwith the sensitivity of 71.6% and the specificity of 66.1%. The best cutoff value for GGT to discriminate MSfrom normal condition was also 16.5 IU with the sensitivity and specificity of 78.4% and 78.4%,respectively. Conclusion: The measuring GGT can be a sensitive method for early diagnosis and predicting IGT and MSfrom normal condition. Because this diagnostic test is a low-cost, highly sensitive, accurate andfrequently used laboratory test, its measurement is recommended as a useful marker of both IGT and MS.
机译：目的：血清γ-谷氨酰转移酶（GGT）升高在预测糖尿病和胰岛素抵抗中的重要作用是明确的;然而，现在假设了GGT水平升高与糖耐量降低（IGT）之间的关系。我们旨在显示GGT测量在IGT诊断中的重要性。材料和方法：从Kerman冠状动脉疾病风险研究（KERCADRS）中随机选择200人作为基于人群的研究。所有参加者均进行了GGT分析测试，此外还测量了代谢综合征（MS）的危险因素和成分。结果：GGT的增加与IGT和MS及其不同成分的患病率增加相关。在多变量分析中，调整了年龄，性别和MS诊断标准后，高GGT与IGT的存在呈正相关。 GGT的曲线下面积（AUC）为0.722，用于将IGT与正常情况区分开，而0.847用于将MS与正常状态区分开。在ROCcurve分析中，GGT区分IGT与正常状态的最佳临界值为20.5 IU，灵敏度为71.6％，特异性为66.1％。 GGT区分MS与正常状态的最佳截止值也为16.5 IU，敏感性和特异性分别为78.4％和78.4％。结论：测量GGT可作为早期诊断和预测正常IGT和MS的灵敏方法。由于该诊断测试是一种低成本，高度灵敏，准确且经常使用的实验室测试，因此建议将其测量值用作IGT和MS的有用标记。

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