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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore
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One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore

机译：新加坡中老年华人的一碳代谢营养状况和血浆S-腺苷甲硫氨酸浓度

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emS/em-adenosylmethionine (SAM) is a primary methyl donor for the methylation of many molecules including DNA. DNA methylation is believed to play an important role in functions of cells and genes. Dietary, genetic and metabolic factors that influence systematic SAM levels are not fully understood. We conducted cross-sectional analysis to evaluate associations between plasma concentrations of one-carbon metabolism nutrients and metabolites and plasma SAM concentrations using healthy individuals within the Singapore Chinese Health Study. Plasma SAM, betaine, choline, folate, total homocysteine (Hcy), methionine, emS/em-adenosylhomocysteine (SAH), vitamin Bsub6/sub and vitamin Bsub12/sub concentrations were quantified. Genotypes of methionine adenosyltransferases (emMAT1A, MAT2A/em and emMAT2B/em) were also determined. Linear regression and path analysis were performed to depict the directed dependencies in one-carbon metabolism. Age and body mass index were positively associated while cigarette smoking were inversely associated with plasma SAM concentrations. Plasma choline, methionine and SAH were positively and strongly associated with plasma SAM after adjustment for confounders. Plasma betaine and folate were positively associated with plasma SAM only in men. Men carrying the variant emMAT1A/em genotypes had lower plasma SAM concentrations than men carrying the wild type genotype (emp/em for gene x gender interaction = 0.02). This effect modification by gender was restricted to individuals with low plasma methionine. In conclusion, plasma choline, methionine and SAH were strongly associated with plasma SAM concentrations. The emMAT1A/em genetic polymorphism may impact plasma SAM concentrations in men with low plasma methionine concentrations.
机译： S -腺苷甲硫氨酸（SAM）是甲基化许多分子（包括DNA）的主要甲基供体。据信DNA甲基化在细胞和基因的功能中起重要作用。影响系统SAM水平的饮食，遗传和代谢因素尚未完全了解。我们进行了横断面分析，以评估新加坡华人健康研究中的健康个体的一碳代谢营养物质和代谢物的血浆浓度与血浆SAM浓度之间的关联。血浆SAM，甜菜碱，胆碱，叶酸，总高半胱氨酸（Hcy），蛋氨酸， S -腺苷同型半胱氨酸（SAH），维生素B 6 和维生素B 12 MAT1A，MAT2A 和 MAT2B ）。进行线性回归和路径分析以描绘一碳代谢中的直接依赖性。年龄和体重指数呈正相关，而吸烟与血浆SAM浓度呈负相关。调整混杂因素后，血浆胆碱，甲硫氨酸和SAH与血浆SAM呈正相关并强烈相关。血浆甜菜碱和叶酸仅与男性血浆SAM正相关。携带变异 MAT1A 基因型的男性的血浆SAM浓度低于携带野生基因型的男性（基因x性别相互作用的 p = 0.02）。性别对这种效果的影响仅限于血浆蛋氨酸含量低的个体。总之，血浆胆碱，蛋氨酸和SAH与血浆SAM浓度密切相关。 MAT1A 基因多态性可能影响血浆蛋氨酸浓度低的男性血浆SAM浓度。

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