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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Plasma soluble receptor for advanced glycation end-products and risk of colorectal adenoma
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Plasma soluble receptor for advanced glycation end-products and risk of colorectal adenoma

机译：血浆可溶性受体，用于晚期糖基化终产物和结直肠腺瘤的风险

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Receptor for advanced glycation end products (RAGE) plays an important role in promoting chronic inflammation with activation of NF-κB. Soluble form of RAGE (sRAGE) represents a naturally occurring competitive inhibitor of RAGE-mediated events. In a colonoscopy-based case-control study, we examined the associations of plasma levels of sRAGE, sTNF-αRI, sTNF-αRII, sIL-6R, EGF, IFNα2, G-CSF, MCP1, TNFβ, and VEGF with risk of colorectal adenoma. We prospectively identified 158 cases with colorectal adenoma and 203 polyp-free controls who were frequency-matched according to age, sex, race, and time of blood draw. Exposure information was collected using a questionnaire and fasting plasma samples were obtained before the colonoscopy. We used Luminex bead-based multiplex assays to determine level of biomarkers. Multivariate logistic regression model was used to estimate odds ratio (OR) and its 95% confidence interval (CI). Cases had insignificant lower levels of sRAGE, and higher levels of EGF and VEGF than controls. When the highest compared with the lowest category, the OR (95% CI) of colorectal adenoma was 0.55 (0.31-0.96) (P trend = 0.03) for sRAGE and 1.75 (1.05-2.93) (P trend =0.04) for VEGF, adjusting for age, smoking status, hypertension and type 2 diabetes. The inverse association between sRAGE and colorectal adenoma was seen only among those without hypertension (P interaction = 0.02). An inverse association between sRAGE and colorectal adenoma was in line with an inverse association between sRAGE and colorectal cancer previously reported. This study supported the involvement of RAGE-NF-kB related inflammatory mechanism in the formation of colorectal adenoma.
机译：晚期糖基化终产物（RAGE）的受体在通过激活NF-κB促进慢性炎症中起重要作用。可溶形式的RAGE（sRAGE）代表RAGE介导事件的天然竞争抑制剂。在一项基于结肠镜检查的病例对照研究中，我们检查了血浆sRAGE，sTNF-αRI，sTNF-αRII，sIL-6R，EGF，IFNα2，G-CSF，MCP1，TNFβ和VEGF与结直肠风险的相关性腺瘤。我们前瞻性地确定了158例结直肠腺瘤患者和203例无息肉对照患者，这些患者根据年龄，性别，种族和抽血时间进行频率匹配。使用问卷收集暴露信息，并在结肠镜检查之前获得空腹血浆样品。我们使用了基于Luminex磁珠的多重测定来确定生物标志物的水平。使用多元逻辑回归模型估计比值比（OR）及其95％置信区间（CI）。与对照组相比，病例的sRAGE水平较低，而EGF和VEGF水平较高。当与最低类别相比最高时，sRAGE的大肠腺瘤的OR（95％CI）为0.55（0.31-0.96）（P趋势= 0.03）和VEGF的1.75（1.05-2.93）（P趋势= 0.04），调整年龄，吸烟状况，高血压和2型糖尿病。 sRAGE和结直肠腺瘤之间的负相关仅在无高血压的患者中可见（P相互作用= 0.02）。 sRAGE和结直肠腺瘤之间的负相关与先前报道的sRAGE和结直肠癌之间的负相关一致。这项研究支持RAGE-NF-kB相关的炎症机制参与结直肠腺瘤的形成。

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