• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Molecular Medicine and Advance Sciences >Non-Neurotropism in Variable Host Cell /Hiv-1 Interactions Determining Neuronal Susceptibility
【24h】

Non-Neurotropism in Variable Host Cell /Hiv-1 Interactions Determining Neuronal Susceptibility

机译：确定神经元易感性的可变宿主细胞/ Hiv-1相互作用中的非神经营养。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A simple concept of directly operative viral neurotropism appears inadequate to explain a full spectrum of phenomena associated with the creation of a viral reservoir as occurs with central nervous system HIV-1 infection. Indeed, a full series of directly and indirectly operative steps would involve peripheral blood monocytes, CNS perivascular cells, vascular endothelia, and resident microglia. In an overall context of a highly integrated CNS and immune system responsiveness, viral encephalitis might actually constitute shifting levels of involvement ranging from dysregulation of cytokine production to autoimmune reactivity to potentially evolving pathways of secondary neuronal injury as by reactive oxygen radicals and phagocytic activity. HIV-1 infection of the CNS, in addition, would appear to add attributes of viral genomic integration and of possible emergence of resistance to anti-retroviral drug therapy to various other mechanisms arising from a central role played by CNS macrophages and microglia beyond a strict concept of viral neurotropism. It appears significant that long-term nonprogressors are selectively predetermined at an early stage in the development of the HIV-1 infected state.
机译：直接作用于病毒的神经向性的简单概念似乎不足以解释与中枢神经系统HIV-1感染所发生的与病毒库建立相关的全部现象。实际上，一系列直接和间接的操作步骤将涉及外周血单核细胞，中枢神经系统血管周围细胞，血管内皮和常驻小胶质细胞。在高度整合的中枢神经系统和免疫系统反应能力的整体背景下，病毒性脑炎实际上可能构成受累水平的变化，范围从细胞因子生产失调到自身免疫反应到继发性神经元损伤的潜在进化途径，如反应性氧自由基和吞噬活性。此外，CNS的HIV-1感染似乎增加了病毒基因组整合的特性，以及对抗逆转录病毒药物疗法产生抗药性的特性，这归因于中枢神经系统巨噬细胞和小胶质细胞在严格控制下所起的核心作用病毒性神经营养的概念。在HIV-1感染状态的发展的早期阶段，有选择地预先确定长期非进展者是很重要的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号