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首页> 外文期刊>International Journal of Nephrology >The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis
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The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis

机译：根除幽门螺杆菌对原发性肾小球肾炎患者蛋白尿的影响

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Background. Membranous nephropathy (MN) is a common cause of nephrotic syndrome. In most cases it is idiopathic, while it may also be secondary to many diseases. In this study, prevalence of H. pylori infection and the effects of H. pylori eradication on proteinuria levels were investigated. Methods. Thirty five patients with MN (19 male), 12 patients with IgA nephropathy (4 male) and 12 patients with focal segmental glomerulosclerosis (FSGS) (8 male) were studied. The presence of H. pylori antigen was investigated in renal tissues obtained by biopsy, and the effects of H. pylori eradication on proteinuria levels were investigated. Results. Immunohistochemistry with H. pylori antigen revealed no positive staining in the glomeruli of all patients. 19 patients (54%) with MN, 10 (83%) with IgA nephropathy and 4 (33%) with FSGS were positive for H. pylori stool antigen test . Patients with H. pylori infection were administered eradication therapy (lansoprazole, 30 mg twice daily, plus amoxicillin, 0.75 g twice daily, plus clarithromycin, 250 mg twice daily, for 14 days). Before the eradication therapy the mean proteinuria of patients with MN, IgA nephropathy and FSGS were 2.42 ± 3.24 g/day, 2.12 ± 1.63 g/day and 1.80 ± 1.32 g/day, respectively. Three months after eradication, baseline proteinuria levels of patients with MN significantly decreased to 1.26 ± 1.73 g/day . In all three groups there were no significant differences with regard to serum creatinine, albumin and C-reactive protein levels before and after eradication therapy. Conclusions. The eradication of H. pylori infection may be effective to reduce proteinuria in patients with MN, while spontaneous remission of MN could not be excluded in this patient cohort. This trial is registered with NCT00983034.
机译：背景。膜性肾病（MN）是肾病综合征的常见病因。在大多数情况下，它是特发性的，同时也可能继发于许多疾病。在这项研究中，调查了幽门螺杆菌感染的流行程度和根除幽门螺杆菌对蛋白尿水平的影响。方法。研究了35例MN患者（19例男性），12例IgA肾病患者（4例男性）和12例局灶性节段性肾小球硬化症（FSGS）（8例男性）。研究了通过活检获得的肾组织中幽门螺杆菌抗原的存在，并研究了幽门螺杆菌根除对蛋白尿水平的影响。结果。幽门螺杆菌抗原的免疫组织化学显示，所有患者的肾小球均无阳性染色。幽门螺杆菌粪便抗原检测呈阳性，其中19例（54％）MN，10例（83％）IgA肾病和4例（33％）FSGS阳性。幽门螺杆菌感染患者接受根除治疗（兰索拉唑，每日两次，每次30μg，加阿莫西林，每日两次，0.75μg，加克拉霉素，每日两次，250μmg，共14天）。根除治疗前，MN，IgA肾病和FSGS患者的平均蛋白尿分别为2.42±3.24μg/天，2.12±1.63μg/天和1.80±1.32μg/天。根除后三个月，MN患者的基线蛋白尿水平显着降低至1.26±1.73μg/天。在所有三组中，根除治疗前后血清肌酐，白蛋白和C反应蛋白水平均无显着差异。结论。根除幽门螺杆菌感染可能有效降低MN患者的蛋白尿，而在该患者队列中不能排除MN的自发缓解。该试用版已在NCT00983034中注册。

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