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首页> 外文期刊>International Journal of Nephrology >The Effects ofHelicobacter pyloriEradication on Proteinuria in Patients with Primary Glomerulonephritis
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The Effects ofHelicobacter pyloriEradication on Proteinuria in Patients with Primary Glomerulonephritis

机译：幽门螺杆菌根除蛋白尿在原发性肾小球肾炎患者中的作用

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Background. Membranous nephropathy (MN) is a common cause of nephrotic syndrome. In most cases it is idiopathic, while it may also be secondary to many diseases. In this study, prevalence ofH. pyloriinfection and the effects ofH. pylorieradication on proteinuria levels were investigated.Methods. Thirty five patients with MN (19 male), 12 patients with IgA nephropathy (4 male) and 12 patients with focal segmental glomerulosclerosis (FSGS) (8 male) were studied. The presence ofH. pyloriantigen was investigated in renal tissues obtained by biopsy, and the effects ofH. pylorieradication on proteinuria levels were investigated.Results. Immunohistochemistry withH. pyloriantigen revealed no positive staining in the glomeruli of all patients. 19 patients (54%) with MN, 10 (83%) with IgA nephropathy and 4 (33%) with FSGS were positive forH. pyloristool antigen test(P=0.045). Patients withH. pyloriinfection were administered eradication therapy (lansoprazole, 30 mg twice daily, plus amoxicillin, 0.75 g twice daily, plus clarithromycin, 250 mg twice daily, for 14 days). Before the eradication therapy the mean proteinuria of patients with MN, IgA nephropathy and FSGS were 2.42 ± 3.24 g/day, 2.12 ± 1.63 g/day and 1.80 ± 1.32 g/day, respectively. Three months after eradication, baseline proteinuria levels of patients with MN significantly decreased to 1.26 ± 1.73 g/day(P=0.031). In all three groups there were no significant differences with regard to serum creatinine, albumin and C-reactive protein levels before and after eradication therapy.Conclusions. The eradication ofH. pyloriinfection may be effective to reduce proteinuria in patients with MN, while spontaneous remission of MN could not be excluded in this patient cohort. This trial is registered withNCT00983034.
机译：背景。膜性肾病（MN）是肾病综合征的常见病因。在大多数情况下，它是特发性的，同时也可能继发于许多疾病。在这项研究中，H的患病率。幽门螺杆菌感染和H的影响研究了幽门螺杆菌根除对蛋白尿水平的影响。研究了35例MN患者（19例男性），12例IgA肾病患者（4例男性）和12例局灶性节段性肾小球硬化症（FSGS）（8例男性）。 H的存在。在通过活检获得的肾组织中研究了幽门抗原，以及H的影响。研究了幽门螺杆菌根除对蛋白尿水平的影响。 H的免疫组织化学。幽门螺杆菌抗原显示所有患者的肾小球均无阳性染色。 MN的19例（54％），IgA肾病的10例（83％）和FSGS的4例（33％）的H阳性。丙酮醇抗原测试（P = 0.045）。 H患者进行幽门螺杆菌感染的根除治疗（兰索拉唑，每日两次，每次30μg，加阿莫西林，每日两次，0.75μg，加克拉霉素，每天两次，250μmg，共14天）。根除治疗前，MN，IgA肾病和FSGS患者的平均蛋白尿分别为2.42±3.24μg/天，2.12±1.63μg/天和1.80±1.32μg/天。根除后三个月，MN患者的基线蛋白尿水平显着降低至1.26±1.73μg/天（P = 0.031）。在所有三组中，根除治疗前后血清肌酐，白蛋白和C反应蛋白水平均无显着差异。根除H。幽门螺杆菌感染可有效减少MN患者的蛋白尿，而在该患者队列中不能排除MN的自发缓解。该试用版已在NCT00983034中注册。

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