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首页> 外文期刊>International journal of MS care >A Topical Adhesive Containing Anesthetic and Heating Components to Reduce Injection Pain with Subcutaneous Multiple Sclerosis Medications
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A Topical Adhesive Containing Anesthetic and Heating Components to Reduce Injection Pain with Subcutaneous Multiple Sclerosis Medications

机译：含有麻醉和加热成分的局部粘合剂，可减少皮下多发性硬化症药物的注射痛

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Background: Injection pain and fear of pain are common with subcutaneous medications for treating multiple sclerosis (MS). Synera is a peel-and-stick topical adhesive (S-TA) with a novel heating component to enhance the delivery of an anesthetic mixture of lidocaine and tetracaine. We studied the effect of S-TA on pain and other aspects of comfort after subcutaneous MS drug injection. Methods: Thirty participants with MS having injection reactions to subcutaneous interferon beta (IFN?) or glatiramer acetate (GA) were enrolled in an open-label prospective study. We captured six to seven injections at baseline and with 60- and 30-minute S-TA application times. The primary outcome was immediate pain on injection. Secondary outcomes included 12- and 24-hour pain ratings, 24-hour local injection-site reaction scale scores, 24-hour tenderness, and fear of injection (FOI). Results: Twenty-nine participants completed the study (interferon beta = 4, GA = 25, mean age = 51 years, females = 86%). There were significant reductions in injection pain, pain at 12 and 24 hours, tenderness at 24 hours, local injection-site reaction scale scores, and FOI for the 30- and 60-minute applications of S-TA (all P < .01). Results were similar in the GA subgroup. Adverse events included muscle spasm and lightheadedness (n = 1) and mild dermatitis (n = 1). Conclusions: These results suggest that S-TA applied 30 or 60 minutes before MS drug injection may reduce pain, tenderness, and FOI. Randomized controlled studies are needed to confirm the efficacy of ST-A.
机译：背景：注射痛和对疼痛的恐惧在治疗多发性硬化症（MS）的皮下药物中很常见。 Synera是一种具有新型加热成分的可剥离粘着局部粘合剂（S-TA），可增强利多卡因和丁卡因麻醉混合物的递送。我们研究了皮下注射MS药物后S-TA对疼痛和其他舒适性方面的影响。方法：30名患有皮下干扰素β（IFNα）或醋酸格拉替雷（GA）注射反应的多发性硬化症患者参加了一项开放标签的前瞻性研究。我们在基线以及60分钟和30分钟的S-TA应用时间捕获了六到七次注射。主要结果是注射时立即疼痛。次要结果包括12小时和24小时疼痛等级，24小时局部注射部位反应量表评分，24小时压痛和注射恐惧感（FOI）。结果：29名参与者完成了研究（干扰素β= 4，GA = 25，平均年龄= 51岁，女性= 86％）。使用S-TA 30分钟和60分钟后，注射疼痛，12和24小时疼痛，24小时压痛，局部注射部位反应量表评分和FOI显着降低（所有P <.01） 。 GA子组的结果相似。不良事件包括肌肉痉挛和头晕（n = 1）和轻度皮炎（n = 1）。结论：这些结果表明，在MS药物注射前30或60分钟应用S-TA可以减轻疼痛，压痛和FOI。需要随机对照研究来确认ST-A的疗效。

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