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首页> 外文期刊>International Journal of Neonatal Screening >Influence of Hematocrit and Total-Spot Volume on Performance Characteristics of Dried Blood Spots for Newborn Screening
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Influence of Hematocrit and Total-Spot Volume on Performance Characteristics of Dried Blood Spots for Newborn Screening

机译：血细胞比容和总斑点体积对新生儿筛查干血斑性能特征的影响

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摘要

Dried blood spots (DBS) have been used in newborn screening (NBS) tests for over 50 years. The Newborn Screening Quality Assurance Program (NSQAP) at the Centers for Disease Control and Prevention (CDC) conducted studies to assess the individual impacts of hematocrit and total-spot volume on characteristics of DBS samples. Per-punch serum volumes decreased 27%, RBC volumes more than doubled, absorption times increased over 300%, and spot diameters decreased marginally between the hematocrits of 40% to 65%. Per-punch serum and RBC volumes decreased logarithmically with lowering total-spot volumes. Patient hematocrit is an uncontrollable variable and inevitably affects the resulting punch from a DBS sample. It may be possible, though, to identify samples that fall outside of an acceptable range by noting certain physical characteristics of the DBS.
机译：干血斑（DBS）在新生儿筛查（NBS）测试中已经使用了50多年。疾病控制和预防中心（CDC）的新生儿筛查质量保证计划（NSQAP）进行了研究，以评估血细胞比容和总斑点量对DBS样品特征的个别影响。每次打孔的血清量减少了27％，RBC量增加了一倍以上，吸收时间增加了300％以上，而血细胞比容之间的斑点直径略有下降，从40％降至65％。每次冲孔的血清和RBC量对数减少，总斑点量降低。病人的血细胞比容是不可控制的变量，不可避免地会影响DBS样本的结果。但是，可以通过注意DBS的某些物理特征来识别超出可接受范围的样本。

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