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首页> 外文期刊>International Journal of Poultry Sciences >Egg Injection of Ascorbic Acid Stimulates Leucocytosis and Cell Proliferation in the Bursa of Fabricius
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Egg Injection of Ascorbic Acid Stimulates Leucocytosis and Cell Proliferation in the Bursa of Fabricius

机译：鸡蛋注射抗坏血酸刺激法氏囊的白细胞增多和细胞增殖

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摘要

Broiler chicks with high immune defense potential at hatching are of great value to the poultry industry. Heat stress can have immunosuppressive or immune stimulatory effect and Ascorbic Acid (AA) acts as anti-stressor and has important physiological functions in bird immune system development. This study aimed to assess the effect of intra egg injection of AA before incubation on development of the bursa of Fabricius and leukocyte parameters in chicks from eggs incubated at thermoneutral and hot temperatures. Fertile eggs from broiler breeder chickens were used in a 5 × 2 factorial design with 5 treatments (non-injected and thus non-perforated and injected with 0, 2, 4 and 6% AA in 100 L of water) and 2 incubation temperatures (thermoneutral: 37.5°C and hot: 39.0°C). The total leukocyte count; percentages of thrombocytes, basophils, eosinophils, monocytes and heterophils; weight; and bursal index remained unaffected by incubation temperature and AA dose. Bursal follicle area decreased in chicks from non-injected eggs when incubated at hot temperatures. With intra egg injection of 4 and 6% AA, bursal follicle size increased in eggs incubated at thermoneutral temperature and decreased at hot temperature compared to no AA injection. Cell proliferation in follicles increased by injecting 2% AA, whereas the percentage of lymphocytes increased by injecting 4 and 6% AA. The data show that AA acts as a dose- and temperature-dependent immunomodulator and that 4 and 6% AA doses stimulate egg bursal development and lymphocytosis. These findings suggest that intra egg injection of AA produces chicks with higher potential for immune defense against challenges in the field.
机译：在孵化中具有高免疫防御潜能的肉鸡对家禽业具有重要价值。热应激可以具有免疫抑制或免疫刺激作用，抗坏血酸（AA）可以起到抗应激作用，并在鸟类免疫系统发育中具有重要的生理功能。这项研究的目的是评估在温育和热温条件下孵化的卵中，在孵化前进行AA卵内注射对雏鸡法氏囊的发展和白细胞参数的影响。肉鸡种鸡的受精卵以5×2析因设计使用，经过5种处理（未注射，因此未穿孔，并在100 L水中注射0、2、4和6％AA）和2个孵育温度（热中性：37.5°C，热中：39.0°C）。总白细胞计数;血小板，嗜碱性粒细胞，嗜酸性粒细胞，单核细胞和嗜异性粒细胞的百分比;重量;培养法温度和AA剂量均不影响法氏囊指数。在高温下温育时，未注射鸡蛋的雏鸡的囊胚毛囊面积减少。卵内注射4和6％的AA时，与不注射AA相比，在热中性温度下孵育的卵中的囊性卵泡大小增加，而在高温下则降低。注射2％的AA可增加卵泡中的细胞增殖，而注射4和6％的AA可增加淋巴细胞的百分比。数据显示，AA充当剂量和温度依赖性免疫调节剂，而4和6％的AA剂量可刺激卵子法氏囊发育和淋巴细胞增多。这些发现表明，卵内注射AA可以使雏鸡具有更高的抵抗野外免疫防御能力的潜力。

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