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首页> 外文期刊>International Journal of Poultry Sciences >Immunization of Broiler with Dead Sporozoites as Vaccine Against Eimeria tenella Parasite
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Immunization of Broiler with Dead Sporozoites as Vaccine Against Eimeria tenella Parasite

机译：死孢子虫作为抗艾美球虫寄生虫疫苗的肉鸡免疫接种

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摘要

Chickens were protected against coccidiosis induced by Eimeria tenella by using 125, 000 dead sporozoites that were injected in neck subcutaneously with two doses at 3rd and 16th days of age. Efficacy of this vaccine was estimated after challenge by determination some parameters like protection rate which was around 96.1-96%. Number of oocysts and cecal lesion score from the chickens in the immunized groups were decreased significantly (0.05<0.01). This vaccine was not effected change on the body weight gain. Also, the immunized groups were higher body weight gain as compare with control groups after challenge. The Anti coccidial index measurement revealed the effectiveness of vaccine considerably. The immunogenicity of vaccine was studied by using SDS-PAGE and Western blot. 7 polypeptides had been estimated more immunogenic after probed with chickens serum at 39 days of age, their molecular weight are (12.3, 13.68, 18.7, 39, 59.5 and 77.3) KD. The results were obtained the feasibility of immunizing Broiler against E. tenella infection by using dead sporozoites as a vaccine.
机译：通过在年龄的第3天和第16天以皮下注射方式向颈部皮下注射125,000个死亡的子孢子，可以保护鸡免受艾美球虫诱导的球虫病的侵袭。攻击后通过确定一些参数（如保护率）约为96.1-96％来评估该疫苗的功效。免疫组鸡卵囊数和盲肠病变评分明显降低（0.05 <0.01）。该疫苗未影响体重增加的变化。此外，免疫组在攻击后比对照组具有更高的体重增加。抗球虫指数的测量显示了疫苗的有效性。通过SDS-PAGE和Western blot研究了疫苗的免疫原性。在39日龄的鸡血清中探查到7种多肽后，据估计具有更高的免疫原性，其分子量分别为（12.3、13.68、18.7、39、59.5和77.3）KD。通过使用死的子孢子作为疫苗，获得了对肉鸡进行抗大肠杆菌的免疫接种的可行性的结果。

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