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首页> 外文期刊>International Journal of Physiology, Pathophysiology and Pharmacology >Tumor associated macrophages deliver iron to tumor cells via Lcn2
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Tumor associated macrophages deliver iron to tumor cells via Lcn2

机译：肿瘤相关的巨噬细胞通过Lcn2将铁传递至肿瘤细胞

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Cancer cells exhibit an increasing iron demand associated with the tumor progression. But the mechanism of iron accumulation in the tumor microenvironment is still unclear. Tumor associated macrophages (TAMs) in the tumor microenvironment may act as extra iron source. However, evidence is still lacking in TAMs as iron donors. In the present study, we found that iron concentration was significantly increased at tumor metastatic stage, which could be attributed to up-regulated expression of lipocalin2 (Lcn2). TAMs in the microenvironment secreted Lcn2. Moreover, TAMs increased intracellular iron concentration in tumor cells via Lcn2 as transporter, which could be restored by Lcn2 antibody neutralization. In conclusion, TAMs increased intracellular iron concentration of the tumor cells via Lcn2 which acted as an iron transporter. Targeting Lcn2 secretion in TAMs to “starve cancer cells” could act as alternative option for tumor therapy.
机译：癌细胞显示出与肿瘤进展相关的铁需求增加。但铁在肿瘤微环境中蓄积的机制仍不清楚。肿瘤微环境中的肿瘤相关巨噬细胞（TAM）可能是多余的铁源。但是，TAM作为铁供体仍缺乏证据。在本研究中，我们发现铁浓度在肿瘤转移阶段显着增加，这可能归因于lipocalin2（Lcn2）的表达上调。微环境中的TAM分泌Lcn2。此外，TAMs通过Lcn2作为转运蛋白增加了肿瘤细胞的细胞内铁浓度，可以通过Lcn2抗体中和来恢复。总之，TAMs通过充当铁转运蛋白的Lcn2增加了肿瘤细胞的细胞内铁浓度。将TAM中Lcn2分泌靶向“饥饿的癌细胞”可以作为肿瘤治疗的替代选择。

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