New insights into Nod-like receptors (NLRs) in liver diseases

Tao Xu; Yan Du; Xiu-Bin Fang; Hao Chen; Dan-Dan Zhou; Yang Wang; Lei Zhang

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New insights into Nod-like receptors (NLRs) in liver diseases

机译：肝脏疾病中Nod样受体（NLR）的新见解

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Activation of inflammatory signaling pathways is of central importance in the pathogenesis of alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Nod-like receptors (NLRs) are intracellular innate immune sensors of microbes and danger signals that control multiple aspects of inflammatory responses. Recent studies demonstrated that NLRs are expressed and activated in innate immune cells as well as in parenchymal cells in the liver. For example, NLRP3 signaling is involved in liver ischemia-reperfusion (I/R) injury and silencing of NLRP3 can protect the liver from I/R injury. In this article, we review the evidence that highlights the critical importance of NLRs in the prevalent liver diseases. The significance of NLR-induced intracellular signaling pathways and cytokine production is also evaluated.

机译：炎症信号通路的激活在酒精性肝病（ALD）和非酒精性脂肪性肝炎（NASH）的发病机理中至关重要。 Nod样受体（NLR）是微生物的细胞内先天免疫传感器，是控制炎症反应多个方面的危险信号。最近的研究表明，NLRs在先天免疫细胞以及肝实质细胞中表达和激活。例如，NLRP3信号传导参与肝脏缺血再灌注（I / R）损伤，而NLRP3沉默可以保护肝脏免受I / R损伤。在本文中，我们将回顾一些证据，这些证据突出了NLR在流行的肝脏疾病中的至关重要性。还评估了NLR诱导的细胞内信号通路和细胞因子产生的意义。

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《International Journal of Physiology, Pathophysiology and Pharmacology》 |2018年第1期|共16页
作者
Tao Xu; Yan Du; Xiu-Bin Fang; Hao Chen; Dan-Dan Zhou; Yang Wang; Lei Zhang;
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中图分类病理学;
关键词
Nod-like receptors (NLRs)liver diseasesNLRP3;

机译：点状受体（NLR）肝脏疾病;

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1. The 2013 3R's event: Toll-like receptors (TLRs), RIG-like receptors (RLRs) & Nod-like receptors (NLRs), London, UK, 19 September 2013 [J] . Ward Christopher James Kevin Immunotherapy . 2014,第1期

机译：2013年3R事件：Toll样受体（TLR），RIG样受体（RLR）和Nod样受体（NLR），英国伦敦，2013年9月19日
2. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders. [J] . Seminars in immunology . 2009,第4期

机译：炎性疾病中的Toll样受体（TLR）和Nod样受体（NLR）。
3. Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism [J] . Gomes Torres Ana Claudia M. B., Leite Neiva, Tureck Luciane Viater, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2019,第期

机译：Toll样受体（TLR）和点状受体（NLR）多态性和脂质和葡萄糖代谢之间的关系
4. The interleukin-1 family cytokines and receptors in autoimmune and autoinflammatory diseases [C] . Lucchesi D., Anzilotti C., Del Corso I., European Congress of Immunology . 2009

机译：自身免疫和自身炎症疾病中白细胞介素-1家族细胞因子和受体
5. Structural insights into the regulatory mechanism of the ryanodine receptor and its disease-associated mutants. [D] . Amador, Fernando. 2013

机译：对ryanodine受体及其疾病相关突变体的调控机制的结构见解。
6. New insights into Nod-like receptors (NLRs) in liver diseases [O] . Tao Xu, Yan Du, Xiu-Bin Fang, 2018

机译：肝脏疾病中Nod样受体（NLR）的新见解
7. Functions of NOD-like receptors (NLRs) in human diseases [O] . Yifei eZhong, Anna eKinio, Maya eSaleh 2013

机译：NOD样受体（NLR）在人类疾病中的功能

New insights into Nod-like receptors (NLRs) in liver diseases

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