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首页> 外文期刊>International Journal of Pharmacological Research >Effects of crude aqueous extracts of Heliotropium indicum Linn (Boraginaceae) on blood pressure in Wistar rats
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Effects of crude aqueous extracts of Heliotropium indicum Linn (Boraginaceae) on blood pressure in Wistar rats

机译：墨竹（Booraginaceae）粗提物对Wistar大鼠血压的影响

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The present work was carried out to investigate the effects of crude aqueous extracts of the stem with leaves and roots of Heliotropium indicum Linn on blood pressure in Wistar rats. Crude aqueous extracts were obtained by decoction of Heliotropium indicum stem with leaves and roots. A phytochemical screening of extracts has been made by thin layer chromatography. The pharmacological effect of the extracts was assessed by administration to L-NAME-induced hypertensive Wistar rats. Blood pressures were measured by carotid catheterization. The chemical screening revealed the presence of many secondary metabolites such as coumarins, flavonoids, anthocyanics, lignans, saponins, tannins, terpenes and triterpenes in both extract. Alkaloid were detected only in the root extract. 7-days administration of L-NAME induced an increasis of rat mean arterial pressure (MAP) from 106±3 mmHg to 134±2 mmHg. Administration of both extracts significantly decreased the MAP from 134±2 mmHg to respectively to 108 ±1 mmHg for the stem with leaf extract and to 121±2 mmHg for the root extract.These results provide a support for the use of this plant in traditional medicine.
机译：目前的工作是为了研究印度棕榈茶茎和叶的粗水提物对Wistar大鼠血压的影响。通过用叶片和根茎煎制印度千日红茎获得粗水提取物。通过薄层色谱法进行了提取物的植物化学筛选。通过对L-NAME诱导的高血压Wistar大鼠给药来评估提取物的药理作用。通过颈动脉导管测量血压。化学筛选显示两种提取物中都存在许多次要代谢产物，如香豆素，类黄酮，花色素，木脂素，皂苷，单宁，萜烯和三萜烯。仅在根提取物中检测到生物碱。服用L-NAME 7天后，大鼠平均动脉压（MAP）从106±3 mmHg增加到134±2 mmHg。两种提取物的施用均使MAP显着降低，叶提取物茎的MAP从134±2 mmHg降至108±1 mmHg，根提取物的MAP降低至121±2 mmHg，这些结果为该植物在传统上的使用提供了支持药物。

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