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首页> 外文期刊>International Journal of Preventive Medicine >Use of Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus and Pre-diabetes and Role of Fasting Plasma Glucose, Oral Glucose Tolerance Test
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Use of Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus and Pre-diabetes and Role of Fasting Plasma Glucose, Oral Glucose Tolerance Test

机译：糖化血红蛋白在糖尿病和糖尿病前期诊断中的应用以及空腹血糖，口服葡萄糖耐量试验的作用

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Background: A highly standardized screening test for newly diagnosis diabetes and pre-diabetes is necessary. the study goal was to clarify the power and efficacy of glycated hemoglobin (HbA1c) in the diagnosis of diabetes and pre-diabetes by comparing against the other American Diabetes Association (ADA) diagnostic criteria of fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT). Methods: This is a retrospective study. A total of 27,001 individuals attended to the internal medicine outpatient clinic between 2006 and 2010 years were screened. All diabetic patients and those using drugs associated with the development of diabetes were excluded. The results of FPG, OGTT and HbA1c for 1814 individual were analyzed and all grouped as diabetic patients, glucose intolerant (pre-diabetes) patients and non-diabetic patients according to new ADA criteria for the diagnosis of diabetes. Results: The prevalence of newly diagnosed diabetes was 69.6% and 54% by using HbA1c alone, 64.2% and 28.2% with 2-h OGTT alone and 43.2% and 60.3%, respectively with FPG alone. Differences between FPG versus 2-h OGTT, FPG versus A1c and OGTT versus A1c were statistically significant ( P 0.0001, P 0.0001 and P = 0.02, respectively). Diagnostic sensitivity of all diabetic criteria was 69.6% for A1c; Nearly, 64.2% for OGTT and only 43.1% for FPG respectively. In terms of diagnostic ratio of glucose intolerance; difference between HbA1C and OGTT was statistically significant ( P 0.0001). Conclusions: As a screening tool for newly diagnosed diabetes and pre-diabetes, the HbA1C level performed better than FPG and 2-h OGTT in this general Saudi population. High diagnostic power of A1C may contribute to the decrease in the number of undiagnosed patients.
机译：背景：对于新诊断的糖尿病和糖尿病前期患者，必须进行高度标准化的筛查。该研究的目的是通过与其他美国糖尿病协会（ADA）的空腹血糖（FPG）和口服葡萄糖耐量试验的诊断标准进行比较，阐明糖化血红蛋白（HbA1c）在糖尿病和糖尿病前期诊断中的功效和功效（OGTT）。方法：这是一项回顾性研究。筛选了2006年至2010年间内科门诊就诊的27,001人。排除所有糖尿病患者和使用与糖尿病发展有关的药物的患者。分析了1814个人的FPG，OGTT和HbA1c结果，并根据新的ADA诊断标准将其分为糖尿病患者，葡萄糖耐量（糖尿病前期）患者和非糖尿病患者。结果：仅使用HbA1c的新诊断糖尿病患病率分别为69.6％和54％，仅使用2-h OGTT的患病率为64.2％和28.2％，仅使用FPG的患病率分别为43.2％和60.3％。 FPG与2小时OGTT，FPG与A1c和OGTT与A1c之间的差异具有统计学意义（分别为P <0.0001，P <0.0001和P = 0.02）。所有糖尿病标准对A1c的诊断敏感性为69.6％; OGTT接近64.2％，FPG仅为43.1％。就葡萄糖耐量的诊断率而言; HbA1C和OGTT之间的差异具有统计学意义（P <0.0001）。结论：作为针对新诊断的糖尿病和糖尿病前期的筛查工具，在该沙特普通人群中，HbA1C水平表现优于FPG和2小时OGTT。 A1C的高诊断能力可能有助于减少未确诊患者的数量。

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