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The Role of GABAB Receptors in Morphine Self-Administration

机译：GABA B受体在吗啡自我管理中的作用

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Background: There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. Methods: This study was performed in four groups of rats: (1) Saline group, which received saline in the self-administration session. (2) Morphine group, which received morphine in saline solution in the self-administration session. (3) Baclofen + Morphine group, which received both baclofen 20 min before self- administration test and morphine in the self-administration session. (4) Phaclofen + Morphine group, which received both phaclofen 20 min before self- administration test and morphine in the self-administration session. The number of lever pressing and self-infusion were recorded. Results: Morphine significantly increased the number of active lever pressing dose dependently in self-administration session in comparative with saline group. Administration of baclofen, 20 min before morphine self-administration produced significant decrease in the initiation of morphine self-administration during all session. Conversely, pre-treatment of phaclofen increased the number of active lever pressing and self-infusion in this test. Conclusion: Our results indicated a short-term treatment by baclofen, reduced morphine-maintenance response in a dose-dependent manner, suggesting that GABAB receptor agonists could be useful for reversing the neuroadaptations related to opiates.
机译：背景：关于GABA受体激动剂和拮抗剂对吗啡自我给药影响的信息很少。本研究旨在评估GABA B受体在吗啡增强的自我管理中的作用。方法：本研究在四组大鼠中进行：（1）盐水组，在自我给药过程中接受生理盐水。 （2）吗啡组，在自给药期间接受了盐溶液中的吗啡。 （3）巴氯芬+吗啡组，在自我给药试验前20分钟接受巴氯芬和在自我给药期间接受吗啡。 （4）Phaclofen +吗啡组，在自我给药试验前20分钟接受phclofen和在自我给药过程中接受吗啡。记录杠杆按压和自输的次数。结果：与盐水组相比，吗啡在自给药期间显着增加了主动杠杆按压剂量的数量。在所有疗程中，在吗啡自我给药前20分钟施用巴氯芬使吗啡自我给药的启动显着减少。相反，在该试验中，phaclofen的预处理增加了主动杠杆按压和自我输注的次数。结论：我们的结果表明巴氯芬可短期治疗，以剂量依赖的方式降低吗啡维持反应，这表明GABA B受体激动剂可能有助于逆转与鸦片有关的神经适应。

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