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首页> 外文期刊>Infectious diseases in obstetrics and gynecology >Epidemiological Study in Okinawa, Japan, of Human Papillomavirus Infection of the Uterine Cervix
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Epidemiological Study in Okinawa, Japan, of Human Papillomavirus Infection of the Uterine Cervix

机译：日本冲绳县人宫颈乳头瘤病毒感染的流行病学研究

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Objective.To investigate the prevalence and type distribution of human papillomavirus (HPV) in women with normal cervical cytology and with cervical intraepithelial neoplasia I to III(CIN) or carcinoma of the cervix in Okinawa, Japan.Methods.We investigated HPV DNA in 4,078 subjects with cytologically normal cervices, 279 subjects with CIN, and 383 subjects with cervical cancer in Okinawa Prefecture in Japan. The presence of HPV DNA was also compared amonggenerations. HPV DNA was both detected and typed using polymerase chain reaction (PCR).Results.The HPV positivity rate was 10.6% in the subjects who were normal on cervical cytodiagnosis. In each generation, the positivity rate was 20.4% in women aged 20–29 years and approximately 10% in the groups aged 30–89 years, with significant differences among generations. The HPV positivity rates in CIN and cervical cancer groups were 76.0% and 86.2%, respectively, with no significant difference between the groups. The positivity rate of HPV 16 decreased with age in both CIN and cervical cancer groups.Conclusion.Among non-cancer subjects, HPV infection rates were almost 20% in women aged 20–29 years and 10% in women aged 30–89 years. HPV16-positive CIN or carcinoma were more prevalent in the younger women, suggesting that HPV16-infected epithelial cells rapidly progress to cervical cancer.
机译：目的：研究日本冲绳，宫颈细胞学正常，宫颈上皮内瘤变I至III（CIN）或子宫颈癌的女性中人乳头瘤病毒（HPV）的患病率和类型分布。方法。在4,078中研究了HPV DNA在日本冲绳县，细胞学正常子宫颈癌患者，279例CIN患者和383例宫颈癌患者。 HPV DNA的存在也进行了比较。结果：对宫颈细胞诊断正常的受试者，HPV阳性率为10.6％。在每一代中，20-29岁女性的阳性率为20.4％，30-89岁女性的阳性率约为10％，各代之间存在显着差异。 CIN组和宫颈癌组的HPV阳性率分别为76.0％和86.2％，两组之间无显着性差异。在CIN和宫颈癌组中，HPV 16的阳性率均随年龄而降低。结论。在非癌症受试者中，HPV感染率在20-29岁的女性中接近20％，在30-89岁的女性中为10％。 HPV16阳性的CIN或癌在年轻女性中更为普遍，这表明被HPV16感染的上皮细胞迅速发展为宫颈癌。

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