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首页> 外文期刊>International Journal of Pharmaceutical Sciences Review and Research >A Study of Changes in Stress Factors during Elective Upper Abdominal Surgery Using Different Anaesthetic Techniques
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A Study of Changes in Stress Factors during Elective Upper Abdominal Surgery Using Different Anaesthetic Techniques

机译：不同麻醉技术在上腹部择期手术中压力因素变化的研究

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Surgical procedures are associated with a complex stress response leading to morbidity as well as mortality. Stress response to surgery activates hypothalamic-pituitary-adrenal axis and the sympathetic nervous system with increase concentration of various stress hormones such as serum cortisol and norepinephrine. During surgery there is a decrease response to insulin action which leads to rise in blood glucose level. It has been suggested that administration of ideal anaesthetic techniques may alleviate the operative stress. Considering the above facts, present study was undertaken to evaluate any role of different anaesthetic techniques, altering the stress factors during upper abdominal surgery. This study was conducted on 120 patients, planned for elective upper abdominal surgery, divided randomly into three demographically identical study groups (A, B and C having 40 patients each). Different anaesthetic techniques such as epidural, general and a combination of both were administered to group A, B and C respectively. It was found that a significant rise (p? 0.05) in serum norepinephrine, cortisol and plasma glucose level at TIMEIn (15 minutes after skin incision is given) and TIMEEND (at the end of surgery) as compared to TIMEBL (baseline value before induction of anaesthesia) among these three groups. Rise in mean serum norepinephrine, cortisol and plasma glucose level both at TIMEIn and TIMEEND of group B patients were found highly significant (p< 0.001) as compared to group C. Similarly these above parameters of group A at TIMEIn and TIMEEND when compared with group C were raised significantly (p< 0.05). So it can be concluded that combination of epidural and general anaesthesia may be considered as best choice in reducing the stress factors in elective upper abdominal surgery.
机译：外科手术与复杂的应激反应相关，导致发病率和死亡率。对手术的应激反应会激活丘脑-垂体-肾上腺轴和交感神经系统，并增加各种应激激素（例如血清皮质醇和去甲肾上腺素）的浓度。在手术过程中，对胰岛素作用的反应降低，导致血糖水平升高。已经提出，施用理想的麻醉技术可以减轻手术压力。考虑到上述事实，本研究旨在评估不同麻醉技术在改变上腹部手术过程中压力因素方面的作用。这项研究针对计划进行选择性上腹部手术的120名患者进行，随机分为三个在人口统计学上相同的研究组（A，B和C各有40名患者）。 A，B和C组分别采用了不同的麻醉技术，例如硬膜外，全身和联合麻醉。结果发现，与TIMEBL（诱导前的基线值）相比，TIMEIn（给予皮肤切开后15分钟）和TIMEEND（手术结束时）的血清去甲肾上腺素，皮质醇和血浆葡萄糖水平显着升高（p <0.05）。这三组麻醉。与C组相比，B组TIMEIn和TIMEEND的平均血清去甲肾上腺素，皮质醇和血浆葡萄糖水平的升高均显着高于P组（p <0.001）。 C显着升高（p ＜0.05）。因此可以得出结论，硬膜外麻醉与全身麻醉相结合可以被认为是减少选择性上腹部手术中压力因素的最佳选择。

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