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首页> 外文期刊>International Journal of Pharmacology >Innovative Food Supplement of Functional Seeds Mixture Improved Bone Mineral Density in Menopausal Egyptian Women
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Innovative Food Supplement of Functional Seeds Mixture Improved Bone Mineral Density in Menopausal Egyptian Women

机译：功能性种子混合物的创新食品补充剂可改善更年期埃及妇女的骨矿物质密度

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Background and Objective: Postmenopausal women frequently have osteoporosis due to deficient estrogen secretion. Phytoesteroids are natural alternatives, of plant origin, can play the role of estrogen substitute in menopause. This study was planned as a trial to formulate a novel safe seeds mixture that supplement important functional nutrients to minimize bone mineral deterioration due to menopause in Egyptian women. Methodology: Mixed dietary supplement was formulated from seeds mixture, grounded to be given to patients on yoghurt. Methanolic and water extract were prepared and analyzed using HPLC, to stand on the present bioactive compounds. Analysis for total isoflavons, polyphenols and antioxidant power were done. Twenty nine postmenopausal women, proved to have bone fragility, supplemented by vitamin D and calcium for at least 2 months, were enrolled in the study. Patients were given 40 g of the seeds mixture twice daily for 3 months. The patients were examined by DEXA (dual energy X-ray densitometry) before and after supplementation. Serum minerals, oxidative marker (MDA) and liver and kidney functions were performed. Serum human procollagen 1 N terminal peptide (P1NT) and osteocalcin bone formation markers were estimated. All data were expressed as Mean±Standard Deviation, differences between groups were detected using t-test. The p Results: Analysis of seed mixture showed high antioxidant capacity, high total isoflavons and polyphenols which are beneficial for bone health. Patient showed significant elevation of T score (p Conclusion: It is concluded that the seed mixture showed valuable effect in improving bone mass density of patients. It has no side effect on organ function. It can be considered as a novel supplement for bone health for post menopausal women having bone fragility.
机译：背景与目的：绝经后妇女由于雌激素分泌不足而经常患有骨质疏松症。植物类固醇是植物来源的天然替代物，可以在绝经中发挥雌激素替代作用。该研究计划作为试验来配制一种新型安全种子混合物，该混合物可补充重要的功能性营养物质，以最大程度地减少埃及妇女因更年期引起的骨矿物质变质。方法：从种子混合物中调配混合膳食补充剂，将其用于酸奶中。制备甲醇和水提取物并使用HPLC分析，以保持本发明的生物活性化合物。进行了总异黄酮，多酚和抗氧化能力的分析。该研究招募了29名绝经后妇女，这些妇女被证明具有骨骼脆弱性，并补充了维生素D和钙至少2个月。每天两次给患者服用40克种子混合物，持续3个月。在补充之前和之后通过DEXA（双能X射线密度测定法）对患者进行检查。进行了血清矿物质，氧化标记（MDA）以及肝和肾功能。血清人胶原蛋白1 N终端肽（P1NT）和骨钙素骨形成标志物被估计。所有数据均表示为平均值±标准差，使用t检验检测组之间的差异。结果：种子混合物的分析显示出高抗氧化能力，高总异黄酮和多酚，对骨骼健康有益。患者的T值显着升高（p结论：结论：这种种子混合物在改善患者的骨密度方面显示出有价值的作用。对器官功能没有副作用。它可以被认为是一种新型的骨骼健康补充剂。绝经后妇女具有骨质脆弱性。

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