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首页> 外文期刊>International Journal of Population Data Science >Linking population-based survey and cancer registry data to examine the association between behaviours consistent with cancer prevention recommendations and cancer risk in Ontario
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Linking population-based survey and cancer registry data to examine the association between behaviours consistent with cancer prevention recommendations and cancer risk in Ontario

机译：将基于人群的调查与癌症登记数据相链接，以检查符合癌症预防建议的行为与安大略省癌症风险之间的关联

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IntroductionCertain subject behaviours and characteristics increase the risk of some cancer types (e.g., obesity, alcohol intake) while others reduce cancer risk (e.g., physical activity). In 2007, the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) published recommendations to reduce cancer risk related to these behaviours. Objectives and ApproachThe objective is to examine the association between self-reported behaviour consistent with WCRF/AICR recommendations for body fatness, physical activity, vegetable/fruit consumption, and alcohol intake and the risk of all cancers combined and specific cancer types. The study cohort, comprised of the Canadian Community Health Survey (CCHS) Ontario sample, will be linked with health administrative databases, including the Ontario Cancer Registry to determine cancer outcomes. Individuals will be assessed for behaviours consistent with WCRF/AICR recommendations based on their responses to CCHS questions and the association of these behaviours with cancer risk will be explored using multivariable Cox proportional hazard regression models. ResultsTo detect a log hazard ratio of 1.10 (where a=0.05, power=0.80, proportion of the sample assigned to the exposure group=0.25 and R2=0.20), a sample size of 4,538 is required. Based on the number of records in the CCHS data frame (159,474) and an assumption that the CCHS sample experiences cancer incidence at a similar rate to the rest of the Ontario population, we expect to have 5,000 cancer cases for these analyses. Upon completion of the analysis, we will report hazard ratios that estimate the difference in cancer risk between individuals reporting behaviour consistent with the WCRF/AICR recommendations and those reporting behaviour not consistent with the recommendations. Conclusion/ImplicationsWCRF/AICR recommendations were developed as the basis for primary cancer prevention, both for individuals and population-wide policies and programs. The current study will quantify the difference in overall cancer risk between individuals who do and do not adhere to selected WCRF/AICR recommendations for the first time in a Canadian population.
机译：简介某些受试者的行为和特征会增加某些癌症类型（例如肥胖，饮酒）的风险，而另一些会降低癌症风险（例如体力活动）。 2007年，世界癌症研究基金会（WCRF）和美国癌症研究所（AICR）发布了降低与这些行为有关的癌症风险的建议。目的和方法目的是检查自我报告的行为与WCRF / AICR建议有关的身体脂肪，身体活动，蔬菜/水果摄入和酒精摄入以及所有癌症合并和特定癌症类型的风险之间的关联。这项由加拿大安大略省社区健康调查（CCHS）样本组成的研究队列将与包括安大略省癌症登记处在内的健康管理数据库联系起来，以确定癌症的结局。将根据他们对CCHS问题的回答，评估与WCRF / AICR建议相一致的行为，并使用多变量Cox比例风险回归模型探索这些行为与癌症风险的关系。结果要检测对数风险比为1.10（其中a = 0.05，功效= 0.80，分配给暴露组的样品比例= 0.25，R2 = 0.20），需要的样品大小为4538。根据CCHS数据框中的记录数（159,474），并假设CCHS样本的癌症发病率与安大略省其他人口相似，我们预计这些分析将有5,000例癌症病例。分析完成后，我们将报告风险比，以估计报告行为与WCRF / AICR建议一致的个体与报告行为与建议不一致的个体之间的癌症风险差异。结论/启示WCRF / AICR建议被开发为个人和整个人群的政策和计划的基础癌症预防的基础。本研究将量化在加拿大人群中首次遵守和不遵守所选WCRF / AICR建议的个体之间总体癌症风险的差异。

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