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首页> 外文期刊>International Journal of Research in Medical Sciences >Antibiotic resistance pattern of bacterial isolates from skin and soft tissue infections
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Antibiotic resistance pattern of bacterial isolates from skin and soft tissue infections

机译：皮肤和软组织感染细菌分离株的抗生素耐药性模式

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Background: Skin and soft tissue infections (SSTIs) are commonly encountered in clinical practice. The spectrum of the causative bacterial agents changes constantly, and so does their antibiogram. Hence, this study was carried out to find the etiological bacterial agents and their antibiotic resistance patterns in cases of SSTIs. Methods: A pus sample was collected aseptically from 328 cases of skin and soft tissue infections attending OPD of a tertiary care hospital and was investigated for antibiotic resistance pattern of isolated organism. Results: Staphylococcus aureus was the commonest pathogen. It showed maximum resistance against penicillin (97.70%) and 100% sensitivity to teicoplanin, linezolid, gentamicin and vancomycin. 75.86% of the isolated S.aureus strains were methicillin sensitive and 24.14% were methicillin resistant. Pseudomonas aeruginosa was the second most frequent isolate. It showed maximum resistance to aztreonam (64.3%), followed by piperacillin, ceftazidime (57.1%) and was completely sensitive to imipenem. Conclusions: Staphylococcus aureus exhibited high resistance to commonly prescribed antibiotics like β-lactams, fluroquinolones and fusidic acid. Hence, it is recommended to base the treatment upon culture and sensitivity report.
机译：背景：皮肤和软组织感染（SSTI）在临床实践中很常见。致病细菌的谱图在不断变化，其抗菌素谱也在变化。因此，进行了这项研究以发现在SSTI病例中的病原细菌制剂及其抗生素耐药性模式。方法：从三级医院OPD的328例皮肤和软组织感染中无菌采集脓液样本，并调查分离菌的抗生素耐药性模式。结果：金黄色葡萄球菌是最常见的病原体。它显示出对青霉素的最大耐药性（97.70％），对替考拉宁，利奈唑胺，庆大霉素和万古霉素的敏感性为100％。分离出的金黄色葡萄球菌菌株中有75.86％对甲氧西林敏感，对甲氧西林有24.14％的耐药性。铜绿假单胞菌是第二常见的分离株。它显示出对氨曲南最大的抵抗力（64.3％），其次是哌拉西林，头孢他啶（57.1％），并且对亚胺培南完全敏感。结论：金黄色葡萄球菌对常用的抗生素如β-内酰胺类，氟喹诺酮类和夫西地酸具有较高的耐药性。因此，建议根据文化和敏感性报告进行治疗。

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