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首页> 外文期刊>International Journal of Research in Medical Sciences >A prospective randomized open label comparative study of efficacy and safety of intralesional measles, mumps, rubella vaccine versus 100% trichloroacetic acid application in the treatment of common warts
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A prospective randomized open label comparative study of efficacy and safety of intralesional measles, mumps, rubella vaccine versus 100% trichloroacetic acid application in the treatment of common warts

机译：病灶内麻疹，腮腺炎，风疹疫苗与100％三氯乙酸治疗普通疣的疗效和安全性进行的前瞻性随机开放标签比较研究

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Background: Treatment of warts represents a continuing challenge for dermatologists as many of the available therapeutic modalities are associated with unsatisfactory results and high recurrence rates. Several clinical trials have proved the efficacy of intralesional immunotherapy by different antigens including MMR vaccine in the treatment of different types of warts. Methods: Total 150 patients having common warts over hands and feet including palmar and plantar warts were included in the study and were randomly divided into two groups. Group 1 consisted of 87 patients in whom MMR vaccine was given intralesionally in the largest wart whereas in Group 2, 63 patients were applied 100% trichloroacetic acid locally to the warts. These treatments were repeated 2 weekly for total three treatments. Patients were assessed for treatment response monthly for 3 months. Results: A highly significant difference was found in the response rates between the two groups (p 75% improvement and 26.44% patients had complete resolution whereas in TCA group, 11.11 % had >75% improvement and 7.94% patients had complete resolution. In the MMR group, side effects included pain at the injection site 100%, flu like symptoms 1.15 %, post-inflammatory hyperpigmentation 1.15% and tenderness 1.15% whereas in the TCA group all patients experienced burning sensation and 2 (3.17%) patients had post-inflammatory hyperpigmentation. Conclusion: Intralesional MMR vaccine is an effective treatment for warts without any significant side effects.
机译：背景：疣的治疗对皮肤科医生来说是一个持续的挑战，因为许多可用的治疗方式都与效果不理想和复发率高有关。数项临床试验已证明，通过包括MMR疫苗在内的不同抗原进行病灶内免疫疗法可治疗不同类型的疣。方法：本研究共纳入150例手脚常见疣，包括手掌和足底疣，并随机分为两组。第1组由87例患者组成，其中在最大的疣内病灶内给予MMR疫苗，而在第2组中，有63例患者对疣局部应用了100％三氯乙酸。每周2次重复上述治疗，共进行3次治疗。每月评估患者3个月的治疗反应。结果：两组之间的反应率存在显着差异（p改善75％，完全缓解的患者为26.44％，而TCA组，改善大于75％的患者为11.11％，完全缓解的患者为7.94％。 MMR组的副作用包括注射部位疼痛100％，流感样症状1.15％，炎症后色素沉着1.15％和压痛1.15％，而在TCA组中，所有患者都有烧灼感，其中2例（3.17％）的患者有烧灼感。结论：肠内MMR疫苗是一种治疗疣的有效方法，无任何明显的副作用。

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