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Modulation of Nrf2/Keap1 pathway by dietary phytochemicals

机译：膳食植物化学物质对Nrf2 / Keap1途径的调节

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Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), also known as NFE2L2, has emerged as a transcription factor that plays a crucial role in cellular protection against free radical damage and reduce the incidence of the radical derived degenerative diseases such as cancer. Nrf2 is a basic leucine zipper transcription factor that binds to ARE leading to induction of a verity of ARE driven detoxification and antioxidant genes. In basal conditions, Nrf2 is sequestered in the cytoplasm by an inhibitory partner the cytoskeletal anchoring protein Kelch-like ECH associated protein-1 (Keap1) through extensive hydrogen bonds. Inducers dissociate this complex, allowing Nrf2 to translocate to the nucleus. A number of studies have elucidated that nutritional compounds can modulate the activation of Nrf2/Keap1 system. This review aims to discuss some of the key nutritional compounds that enhance the activation of Nrf2, with consequent antioxidant and anti-inflammatory defensive effects.
机译：核因子（类胡萝卜素衍生的2）样2（Nrf2），也称为NFE2L2，已作为转录因子出现，在细胞保护细胞免受自由基损害中起着至关重要的作用，并减少了自由基衍生的变性疾病的发生，例如癌症。 Nrf2是一种基本的亮氨酸拉链转录因子，与ARE结合，导致诱导ARE驱动的排毒和抗氧化剂基因的真实性。在基础条件下，Nrf2通过广泛的氢键被抑制性伴侣细胞骨架锚定蛋白Kelch-like ECH相关蛋白1（Keap1）螯合在细胞质中。诱导剂使这种复合物解离，从而使Nrf2易位至细胞核。大量研究表明，营养化合物可以调节Nrf2 / Keap1系统的激活。这篇综述旨在讨论一些增强Nrf2活化并因此具有抗氧化和抗炎防御作用的关键营养化合物。

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