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首页> 外文期刊>International Journal of Research in Medical Sciences >Splenotoxic effect of radiographic developer effluent on Wistar rats
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Splenotoxic effect of radiographic developer effluent on Wistar rats

机译：放射显影剂对Wistar大鼠的脾毒性作用

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Background: Histological changes associated with toxicity of radiographic developer effluents on spleen tissues have not been previously studied. The present study therefore aimed at demonstrating the histopathological changes in splenic tissues of Wistar rats following exposure to developer effluent. Methods: Eighteen young Wistar rats weighing 140-220g were used for the study. The animals were divided randomly into three groups of 6 rats each based on the dose of developer effluent administered to them - i.e. control group I (0 dose) and experimental groups II (lower dose, 200 mg/kg) and III (higher dose, 400 mg/kg) respectively. The groups were further classified as either A or B sub-groups of three rats each, depending on the duration (14 or 28 days) of effluent administration. The effluent administration was done by oral gavages. Results: Normal spleen histology was observed in the control group. In contrast, tissue degeneration and necrosis; lymphocytic infiltration as well as reduction of splenic follicles were observed in some of the test groups (IIA, IIB and IIIA). Interestingly, the toxic effects of the developer effluent on group IIIB administered with higher dose for a longer period of 28 days were not as severe as observed in the other test groups. Conclusions: The present study which indicated adverse effects of exposures to sub-lethal doses of developer effluent on Wistar rats' spleen tissues suggests the need for proper management and disposal of radiographic effluents.
机译：背景：与射线照相显影液对脾脏组织毒性相关的组织学变化以前尚未进行过研究。因此，本研究旨在证明暴露于显影液后的Wistar大鼠脾组织的组织病理学变化。方法：使用18只体重为140-220g的Wistar大鼠进行研究。将动物随机分为三组，每组六只，分别根据给它们施加的显影液的剂量-即对照组I（0剂量）和实验组II（较低剂量，200 mg / kg）和III组（较高剂量， 400 mg / kg）。根据出水的持续时间（14天或28天），将这些组进一步分为每组三只大鼠的A或B亚组。出水通过口管进行。结果：对照组脾脏组织学正常。相反，组织变性和坏死;在某些测试组（IIA，IIB和IIIA）中观察到淋巴细胞浸润以及脾泡减少。有趣的是，显影液对28B较长剂量高剂量IIIB组的毒性作用不如其他试验组严重。结论：本研究表明暴露于亚致死剂量的显影液对Wistar大鼠的脾脏组织有不利影响，提示需要适当处理和处置放射照相的废水。

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