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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Determination of frequency of specified structural congenital anomalies and the pattern of determinants affecting congenital malformations in prenatally diagnosed fetal anomaly cases before 20 weeks
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Determination of frequency of specified structural congenital anomalies and the pattern of determinants affecting congenital malformations in prenatally diagnosed fetal anomaly cases before 20 weeks

机译：在20周前确定产前诊断的胎儿异常病例中特定的结构性先天性异常的频率以及影响先天性畸形的决定因素的模式

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Background: Congenital anomalies accounts for 8-15% of perinatal deaths and 13-16% of neonatal deaths in India. The aim of this study was to determine frequency of specified structural congenital anomalies and the pattern of determinants affecting congenital malformations in prenatally diagnosed fetal anomaly cases before 20 weeks Methods: The present study was conducted at Kamla Nehru State Hospital for Mother and Child, Indira Gandhi Medical College, Shimla. During the study period, all pregnant women with prenatally diagnosed fetal anomaly before 20 weeks, reporting to the Department of OBG, were enrolled for this non-interventional prospective observational study. The observations were analysed on a statistical basis in structured data collection form. Results: Congenital malformations were significantly more common in the age groups of 20-30 years, of low socioeconomic status, vegetarians and who were non-compliant regarding folic acid intake. The majority of women bearing malformed foetuses came from areas at altitude of 500-2000 meters. 33.33% of foetuses had amniotic fluid abnormalities. 83.33% of the foetuses had a single malformation. Central nervous system was the most common system involved (61.90%) out of which neural tube defects (76.91%) were commonest. 11.9% malformations were of the gastrointestinal tract out of which majority (60%) were omphalocele. 4.76% of the total malformations were of the musculoskeletal system. 4.76% malformations involved the genito-urinary tract and 2.38% of the total malformations were of the cardiovascular system and craniofascial anomalies. Conclusions: Early detection of major malformation during pregnancy helps in reducing the high morbidity and mortality of neonates due to congenital malformations because of termination of pregnancy. The commonest system found to be affected was central nervous system followed by gastro-intestinal system. Food fortification with folates and vitamin B12 is the need of the hour.
机译：背景：在印度，先天性异常占围产期死亡的8-15％，占新生儿死亡的13-16％。这项研究的目的是确定20周前在产前诊断出的胎儿异常病例中特定的结构性先天性异常的频率和影响先天性畸形的决定因素的模式。西姆拉医学院。在研究期间，所有向OBG部报告的在20周之前具有产前诊断为胎儿异常的孕妇均参加了这项非干预性前瞻性观察研究。在统计基础上以结构化数据收集形式对观察结果进行分析。结果：先天性畸形在20至30岁年龄段，社会经济地位低下，素食主义者以及对叶酸摄入不服从的人群中更为常见。大多数携带畸形胎儿的妇女来自海拔500-2000米的地区。 33.33％的胎儿有羊水异常。 83.33％的胎儿患有单个畸形。中枢神经系统是最常见的系统（61.90％），其中神经管缺陷最多（76.91％）。 11.9％的畸形是胃肠道畸形，其中大部分（60％）是食管膨出。总畸形的4.76％是肌肉骨骼系统。 4.76％的畸形累及生殖泌尿道，占总畸形的2.38％是心血管系统和颅面筋膜异常。结论：妊娠早期重大畸形的早期发现有助于降低因终止妊娠而导致的先天畸形所致的新生儿的高发病率和死亡率。发现最常见的系统是中枢神经系统，其次是胃肠系统。叶酸和维生素B12强化食品是一个小时的需要。

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