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METHOD FOR FEMALE SCREENING FOR PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES AND INTRAUTERINE INFECTION OF FOETUS

机译：胎儿先天性异常的产前诊断和子宫内感染的女性检查方法

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FIELD: medicine.;SUBSTANCE: method involves three ultrasound examinations on the 10-14th week, the 20-24th week, the 30-34th week of pregnancy, as well as two biochemical mother's blood analyses. The examination provides a basis to evaluate an individual risk of prenatal congenital malformations. The first biochemical analysis on the 9-13th week involves evaluating pregnancy associated protein A (PAPP-A) and human beta-chorionic gonadotropin. The second analysis on the 15-18th week is conducted to determine the content of alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). The risk of congenital malformations exceeding 1:360 (0.28%) observed on the 15-18th week requires additional mother's blood serum analysis for the content of lactoferrin (LF) and trophoblastic beta-1-glycoprotein (TBG) by solid-phase immune-enzyme assay. If the LF concentration is more than 4.5 mcg/ml and the TBG concentration is more than 200000 ng/ml, a high risk of intrauterine infection and fetopathy of infectious genesis is diagnosed in the foetus, and the etiotropic antibacterial therapy is recommended. If the LF concentration is less than 3.0 mcg/ml and the TBG concentration is more than 100000 ng/ml, a low risk of developing intrauterine infection and fetopathy of infectious genesis is diagnosed in the foetus, and the case follow-up is recommended.;EFFECT: higher screening accuracy that enables reducing a disease rate and newborn death rate considerably.;3 ex

机译：领域：医学;研究对象：该方法涉及在怀孕的第10-14周，第20-24周，第30-34周进行三次超声检查，以及两次生化母亲的血液分析。该检查为评估个人产前先天性畸形的风险提供了基础。第9-13周的首次生化分析涉及评估妊娠相关蛋白A（PAPP-A）和人β-绒毛膜促性腺激素。在15-18周进行第二次分析，以确定甲胎蛋白（AFP）和人绒毛膜促性腺激素（HCG）的含量。在15-18周观察到的先天性畸形风险超过1：360（0.28％），需要通过固相免疫法对母亲的血清中的乳铁蛋白（LF）和滋养细胞β-1-糖蛋白（TBG）含量进行额外的母亲血清分析酶测定。如果LF浓度大于4.5 mcg / ml，TBG浓度大于200000 ng / ml，则可在胎儿中诊断出宫内感染和感染性胎儿形成病的高风险，并建议进行正离子抗菌治疗。如果LF浓度小于3.0 mcg / ml，TBG浓度大于100000 ng / ml，则胎儿体内诊断为发生宫内感染和感染性胎儿病的风险较低，建议进行病例随访。效果：更高的筛查准确性可显着降低疾病发生率和新生儿死亡率。

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公开/公告号RU2461006C1

专利类型
公开/公告日2012-09-10

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申请/专利权人 MUNITSIPALNOE BJUDZHETNOE LECHEBNO-PROFILAKTICHESKOE UCHREZHDENIE ZONALNYJ PERINATALNYJ TSENTR;GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE DOPOLNITELNOGO PROFESSIONALNOGO OBRAZOVANIJA NOVOKUZNETSKIJ GOSUDARSTVENNYJ INSTITUT USOVERSHENSTVOVANIJA VRACHEJ MINISTERSTVA ZDRAVOOKHRANENIJA I SOTSIALNOGO RAZVITIJA ROSSIJSKOJ FEDERATS;
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申请/专利号RU20110122077
发明设计人 ZORINA VERONIKA NIKOLAEVNA;POLUKAROV ANDREJ NIKOLAEVICH;BAZHENOVA LJUDMILA GRIGOREVNA;BOTVINEVA IRINA ANATOLEVNA;RENGE LJUDMILA VLADIMIROVNA;
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申请日2011-05-31
分类号G01N33/50;
国家 RU
入库时间 2022-08-21 17:05:55

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