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首页> 外文期刊>International Journal of Research in Medical Sciences >Isolation and antibiotic susceptibility of bacteria from foot infections in the patients with diabetes mellitus type I and type II in the district of Kancheepuram, Tamil Nadu, India
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Isolation and antibiotic susceptibility of bacteria from foot infections in the patients with diabetes mellitus type I and type II in the district of Kancheepuram, Tamil Nadu, India

机译：印度泰米尔纳德邦Kancheepuram地区I型和II型糖尿病患者足部感染细菌的分离和抗生素敏感性

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Background: Diabetic foot infections are important cause of morbidity and mortality among persons with diabetes mellitus. The reported prevalence rates in India range from 0.9-8.3%. Diabetes foot lesions are the leading cause of non-traumatic amputations worldwide. A study has been conducted to isolate and find the antibiotic susceptibility pattern of the bacteria from diabetic foot infections from the patients of Kancheepuram district, Tamil Nadu, India. Methods: Sixty patients previously diagnosed or newly diagnosed as diabetic, presented with lower extremity infection attending Tagore medical college and hospital and its peripheral centres were selected for the study. Various specimens (pus, wound exudates, or tissues biopsy) for microbiological studies were obtained from the infected region. The specimens were cultured on blood agar and MacConkey agar for aerobic / facultative anaerobic organisms and on Neomycin Blood Agar for anaerobic organism. The plates were then incubated at 37°C. For anaerobic culture the plates were incubated in the McIntosh anaerobic jar. Isolates obtained are identified by standard laboratory techniques. Results: The result showed that Pseudomonas aeruginosa (48.3%) is the predominant bacterium followed by Staphylococcus aureus (38%) and other bacteria. The anaerobic bacteria are also isolated from the diabetic foot ulcers. The Peptostreptococcus species (26.7%) are the predominant bacteria followed by other bacteria. Further the results showed that 22 patients (37%) showed the multi-bacterial infection and remaining 38 patients (63%) showed mono bacterial infection. The drugs like amikacin, cefepine, ciprofloxacin, cotrimoxazole and roxythromycin are sensitive to many gram positive bacterial isolates. Conclusion: The present study has given the data of various bacteria encountered in the diabetic foot ulcer in the district of Kancheepuram, Tamil Nadu, India and its antibiotic sensitivity pattern. The results clearly reveal that there is no definite aetiology in diabetic foot infections. Many patients presented the infection with the involvement of many bacteria. Further it is evident that many bacteria are multi drug resistant and thus complicating the management of diabetic foot infections.
机译：背景：糖尿病足感染是糖尿病患者发病和死亡的重要原因。据报道，印度的患病率在0.9-8.3％之间。糖尿病足病变是世界范围内非创伤性截肢的主要原因。已经进行了一项研究，以从印度泰米尔纳德邦的坎奇普勒姆地区的糖尿病足感染患者中分离和发现细菌的抗生素敏感性模式。方法：选择在泰戈尔医学院和医院及其周边中心就诊的60例先前被诊断或新诊断为糖尿病的下肢感染患者。从感染区域获得了用于微生物学研究的各种标本（脓液，伤口渗出液或组织活检）。将标本分别培养在血琼脂和MacConkey琼脂上培养好氧/兼性厌氧生物，并在新霉素血琼脂上培养厌氧菌。然后将板在37℃下孵育。对于厌氧培养，将板在McIntosh厌氧罐中孵育。通过标准实验室技术鉴定获得的分离物。结果：结果表明，铜绿假单胞菌（48.3％）是主要细菌，其次是金黄色葡萄球菌（38％）和其他细菌。还从糖尿病足溃疡中分离出厌氧细菌。肽链球菌种类（26.7％）是主要细菌，其次是其他细菌。进一步的结果表明，22例患者（37％）表现出多细菌感染，其余38例患者（63％）表现出单细菌感染。诸如丁胺卡那霉素，头孢地平，环丙沙星，卡曲美唑和雷莫霉素的药物对许多革兰氏阳性细菌分离株敏感。结论：本研究提供了印度泰米尔纳德邦坎奇普勒姆地区糖尿病足溃疡中遇到的各种细菌的数据及其抗生素敏感性模式。结果清楚地表明，糖尿病足感染没有明确的病因。许多患者表现出感染，其中涉及许多细菌。此外，很明显，许多细菌具有多重耐药性，因此使糖尿病足感染的管理变得复杂。

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