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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >Using platelet-to-lymphocyte ratio as a diagnostic marker in malignant ovarian tumors
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Using platelet-to-lymphocyte ratio as a diagnostic marker in malignant ovarian tumors

机译：使用血小板与淋巴细胞之比作为卵巢恶性肿瘤的诊断指标

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Background: Ovarian malignancy, is the fifth global fatal disease for women, and the most common cause of death in Gynecological cancer. Objective was to evaluate any diagnostic role of Platelet-to-lymphocyte ratio in epithelial ovarian tumors. Methods: A prospective analysis, over 1 year; (October 2016 to October 2017). Setting: University hospital’s Gynaecological oncology centre. Subjects & Methodology: A total of 36 patients with epithelial ovarian tumors, not under any adjuvant therapy and negative for any other malignancy, or any blood diseases causing blood count changes. All subjects underwent preoperative assessment of CA125 and Platelet-to-lymphocyte ratio (PLR), followed by a staging laparotomy and the appropriate management according to the standard protocols. Postoperative histopathological confirmation of the disease type, stage and grade was done for all cases. Results: (77.8%) of the patients had early stage disease while (22.2%) had advanced stage. Neither mean platelet, lymphocytic counts, nor PLR express any significant difference between early and late stage disease. CA 125 levels, however changed significantly in advanced stages. PLR showed a statistically significant difference between the three stages of the disease (P=0.007). There was a positive correlation between PLR and CA125 (r=0.184 and P=0.283). Conclusions: PLR rise significantly with tumor stages and correlates significantly with CA125. No significant change in PLR values with tumor type or grade. PLR might be a potential diagnostic / prognostic marker of ovarian epithelial cancer.
机译：背景：卵巢恶性肿瘤是女性的第五大致命性疾病，也是妇科癌症中最常见的死亡原因。目的是评估血小板与淋巴细胞之比在上皮性卵巢肿瘤中的诊断作用。方法：前瞻性分析，一年以上; （2016年10月至2017年10月）。地点：大学医院的妇科肿瘤中心。受试者与方法：共有36例上皮性卵巢肿瘤患者，未接受任何辅助治疗且对任何其他恶性肿瘤或任何引起血液计数变化的血液疾病均呈阴性。所有受试者均接受术前CA125和血小板与淋巴细胞比率（PLR）评估，然后进行分期剖腹术并根据标准方案进行适当管理。所有病例均进行了术后病理组织学检查，确定了疾病的类型，阶段和等级。结果：（77.8％）患者患有早期疾病，而（22.2％）患者处于晚期。早期和晚期疾病之间的平均血小板计数，淋巴细胞计数或PLR均无明显差异。但是，CA 125的水平在晚期阶段发生了显着变化。 PLR在疾病的三个阶段之间显示出统计学上的显着差异（P = 0.007）。 PLR和CA125之间存在正相关（r = 0.184和P = 0.283）。结论：PLR与肿瘤分期显着升高，并与CA125显着相关。肿瘤类型或等级的PLR值无明显变化。 PLR可能是卵巢上皮癌的潜在诊断/预后标志物。

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