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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >PCOS in adolescence: effect of metformin on menstrual irregularities
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PCOS in adolescence: effect of metformin on menstrual irregularities

机译：青春期PCOS：二甲双胍对月经不调的影响

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Background: PCOS is an endocrine disorder affecting women across lifespan, initially a disease of the females in the child bearing age group, nowadays maximum adolescent females also present with PCOS. Adolescence PCOS is a heterogenous endocrine disorder diagnosed in 5% to 10% of adolescent girls and is one of the major causes of adolescent hyperandrogenism and menstrual irregularity. Thus, this study was carried out to study the effect of Metformin on adolescent patients with PCOS on Weight reduction and Regularization of Menstrual cycle. Secondary objective is to study the occurrences of various manifestations in patients with PCOS. Methods: Patients aged 10-20 years diagnosed PCOS attending the outpatient department of OBGY over a period of two years were included in the study. Out of 100 patients, 20 patients were excluded because of other causes of anovulation viz thyroid abnormalities, prolactin level abnormalities and patients who did not turn up for follow up. Study was done on 80 patients of PCOS. Patients were divided into two groups A and B. Group A (n=40) received 500 mgs Metformin and Group B (n=40) received placebo. Results were analysed using statistical package of social sciences (SPSS) 21.0. Statistical significance was set at p ≤0.05. Results: In the present study Irregular cycle was the commonest occurring menstrual irregularity. Menstrual Cycle was regularised in 95% of the study group while only 35% of the control group. 85% patients in the present test group had lost weight at the end of 6 months while only 55% in the control group had lost weight in 6 months. Thus A 6-month course of metformin improves menstrual cyclicity in women with the PCOS. Conclusions: In patients with PCOS, the addition of insulin sensitizers viz metformin along with diet and lifestyle modifications has resulted in significant weight loss and improvement in cyclicity of menstrual cycle. Thus, Insulin-sensitizing agents provide a rational approach to the treatment of the metabolic and endocrine abnormalities in PCOS women.
机译：背景：多囊卵巢综合征是一种内分泌失调，影响到整个寿命的妇女，最初是育龄妇女中的一种女性疾病，如今，最多的青春期女性也患有多囊卵巢综合征。青春期PCOS是一种异质性内分泌疾病，在5％至10％的青春期女孩中被诊断出来，并且是青春期雄激素过多和月经不调的主要原因之一。因此，本研究旨在研究二甲双胍对青春期PCOS患者减轻体重和调整月经周期的影响。次要目的是研究PCOS患者各种表现形式的发生。方法：本研究包括两年内在OBGY门诊就诊的诊断为PCOS的10-20岁患者。在100例患者中，有20例患者因其他原因引起的无排卵即甲状腺异常，催乳素水平异常以及未接受随访的患者而被排除在外。对80例PCOS患者进行了研究。患者分为A组和B组。A组（n = 40）接受500 mg二甲双胍，B组（n = 40）接受安慰剂。使用社会科学统计软件包（SPSS）21.0分析结果。统计学显着性设定为p≤0.05。结果：在本研究中，月经不调是最常见的月经不调。 95％的研究组的月经周期正常化，而对照组的只有35％。本试验组中85％的患者在6个月末体重减轻，而对照组中只有55％的患者在6个月末体重减轻。因此，二甲双胍为期6个月的疗程可改善患有PCOS的女性的月经周期。结论：在患有PCOS的患者中，添加胰岛素增敏剂即二甲双胍，以及饮食和生活方式的改变，可导致体重明显减轻，月经周期的改善。因此，胰岛素增敏剂为治疗PCOS妇女的代谢和内分泌异常提供了一种合理的方法。

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