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首页> 外文期刊>International Journal of Reproduction, Contraception, Obstetrics and Gynecology >A comparative study of efficacy of oxytocin, methylergometrine and misoprostol in prevention of post-partum haemorrhage
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A comparative study of efficacy of oxytocin, methylergometrine and misoprostol in prevention of post-partum haemorrhage

机译：催产素，甲基麦角新烯酮和米索前列醇预防产后出血的疗效比较研究

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Background: To compare the efficacy of oxytocin, methylergometrine and misoprostol in active management of third stage of labour (AMTSL). Methods: A clinical study was conducted on 330 low risk pregnant women with a healthy singleton pregnancy and spontaneous onset of labour at term; allocated into three groups where active management of third stage of labour was done with either Oxytocin 10 IU intramuscular, or Methylergometrine 0.2 mg intramuscular, or tab Misoprostol 600μg sublingual on 110 women each group. Primary parameter was blood loss during labour. Secondary parameters were the duration of third stage of labour and changes in haemoglobin level. Results: Blood loss during labour in Oxytocin group was 145.86±11.53 ml, which was significantly less than that in Methylergometrine (164.02±9.36 ml) and Misoprostol groups (183.18±9.70 ml), but no patient in any of the groups had blood loss more than 200ml. Duration of third stage of labour was significantly less in Oxytocin group (5.13±1.91 mins) than in. Methylergometrine (6.16±1.85 mins), and Misoprostol groups (6.47±1.51 mins). No patient had prolonged third stage in any of the groups. There was no significant change in pre-and post-delivery haemoglobin levels in all the groups. Conclusions: Though injectable uterotonics are effective for active management of third stage of labour (AMTSL), misoprostol can also be effectively used, especially in settings where there is no adequate trained personnel and drug storage facility.
机译：背景：为了比较催产素，甲基麦角新烯酮和米索前列醇在积极管理第三产程（AMTSL）中的功效。方法：对330例健康，单身妊娠，足月自然分娩的低危孕妇进行临床研究。分为三组，每组110名女性使用催产素10 IU肌内注射或甲基麦角新碱0.2 mg肌内注射或米索前列醇600μg舌下舌下有效管理第三产程。主要参数是分娩时失血。次要参数是第三产程的持续时间和血红蛋白水平的变化。结果：催产素组分娩时失血量为145.86±11.53 ml，明显低于甲基麦角新烯酮（164.02±9.36 ml）和米索前列醇组（183.18±9.70 ml），但各组均无失血量200ml以上。催产素组（5.13±1.91分钟）的第三产程持续时间明显少于甲基麦角新烯酮（6.16±1.85分钟）和米索前列醇组（6.47±1.51分钟）。在所有组中，没有患者延长第三阶段的治疗。所有组的分娩前后血红蛋白水平均无显着变化。结论：尽管可注射子宫内避孕药可有效地管理第三产程（AMTSL），但米索前列醇也可有效使用，特别是在没有足够的受过训练的人员和药物存储设施的地方。

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