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首页> 外文期刊>International journal of rheumatology >Carotid Intima Media Thickness as a Marker of Atherosclerosis in Ankylosing Spondylitis
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Carotid Intima Media Thickness as a Marker of Atherosclerosis in Ankylosing Spondylitis

机译：颈动脉内膜中层厚度作为强直性脊柱炎动脉粥样硬化的标志

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Aim. Increased cardiovascular morbidity and mortality have been observed in ankylosing spondylitis because of accelerated atherosclerosis. We measured carotid intima media thickness (CIMT) as a surrogate marker of atherosclerosis in this study.Methods. In this study 37 cases of AS and the same number of matched individuals were recruited. CIMT measurements were done using B-mode ultrasound. Disease activity was assessed using Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), and Bath ankylosing spondylitis metrological index (BASMI) scores and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels.Results. Mean age of the study groups was 29.43 ± 9.00 years. Average disease duration was 65.62 ± 54.92 months. Twenty-eight (75.68%) of cases were HLA B-27 positive. A significantly increased CIMT was observed in cases as compared to control group (0.62 ± 0.12 versus 0.54 ± 0.04;P<0.001). CIMT in the cases group positively correlated with age(r=0.357; P<0.05), duration of disease(r=0.549; P<0.01), and BASMI(r=0.337; P<0.05)and negatively correlated with ESR(r=−0.295; P<0.05).Conclusions. Patients of AS had a higher CIMT than those of the control group. CIMT correlated with disease chronicity.
机译：目标。由于加速的动脉粥样硬化，在强直性脊柱炎中发现心血管疾病的发病率和死亡率增加。在这项研究中，我们测量了颈动脉内膜中层厚度（CIMT）作为动脉粥样硬化的替代指标。在这项研究中，招募了37例AS和相同数量的匹配个体。 CIMT测量是使用B型超声进行的。使用巴斯强直性脊柱炎疾病活动指数（BASDAI），巴斯强直性脊柱炎功能指数（BASFI）和巴斯强直性脊柱炎计量指数（BASMI）评分，C反应蛋白（CRP）和红细胞沉降率（ESR）水平评估疾病活动结果。研究组的平均年龄为29.43±9.00岁。平均病程为65.62±54.92个月。 28例（75.68％）病例为HLA B-27阳性。与对照组相比，病例的CIMT显着增加（0.62±0.12比0.54±0.04; P <0.001）。病例组的CIMT与年龄（r = 0.357; P <0.05），病程（r = 0.549; P <0.01）和BASMI（r = 0.337; P <0.05）正相关，与ESR（r = -0.295; P <0.05）。结论。 AS患者的CIMT高于对照组。 CIMT与疾病的慢性相关。

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